09Mon

Chairs

• Andrea Schietinger, Memorial Sloan Kettering Cancer Ctr.
• David Masopust, Univ. of Minnesota

Speakers

• Michael William Rudloff, Vanderbilt Univ. Med. Ctr., Hallmark features of T cell dysfunction are established within hours after tumor antigen encounter
• Nataliya Prokhnevska, Emory Univ., CD8 T cell activation in cancer is comprised of two distinct phases
• Hazem E. Ghoneim, Ohio State Univ. Col. of Med., Rebalancing TGFβ1/BMP Signaling Epigenetically Reprograms Fully Exhausted Human CD8 T Cells into a Functional State
• Benjamin M. Murter, Univ. of Pittsburgh Sch. of Med., PIK3IP1/TrIP Immune Regulation on CD8⁺ T Cells Restricts Anti-Tumor Immunity
• Rachel Cantrell, Univ. of Cincinnati Col. of Med., The role of the Thrombin/PAR axis in modulating CD8+ T cell anti-tumor immunity
• Haitao Wen, Ohio State Univ., Sushi domain containing 2 suppresses CD8⁺ T cell antitumor immunity by targeting IL-2 receptor signaling
• Emily C. Lerner, Duke Univ. Sch. of Med., CD8 T cells licensed with immune checkpoint blockade kill murine tumors lacking MHC-I
• Pamela Rosato, Geisel Sch. of Med., Dartmouth Col., Functional virus-specific memory CD8+ T cells survey glioblastoma

Chairs

• Craig L. Maynard, Univ. of Alabama at Birmingham
• Meghan A. Koch, Fred Hutchinson Cancer Res. Ctr.

Speakers

• Susan Kovats, Oklahoma Med. Res. Fndn., Androgens protect ILC2s from interferon-mediated functional suppression during influenza virus infection
• Kaylyn Bauer, Univ. of Utah, Rab27A-dependent transfer of CD11c+ cell exosomes regulate gut immunity
• Marina Chulkina, Pennsylvania State Univ. Col. of Med., MyD88-mediated signaling in myo-/fibroblasts is required for control of macrophage maturation under mucosal tolerance in the gut
• Emma Erlich, Washington Univ. in St Louis Sch. of Med., B cells drive tertiary lymphoid organ formation in ileal inflammation
• Andrea Reboldi, Univ. of Massachusetts Med. Sch., IgA B cell receptor signaling protects from FasL counterselection during germinal center reaction in Peyer’s patches and shapes humoral mucosal response.
• Jason L. Kubinak, Univ. of South Carolina Sch. of Med., Defective humoral immunity disrupts bile acid homeostasis which promotes inflammatory disease of the small bowel
• Elisa Cruz Morales, Perelman Sch. of Med., Univ. of Pennsylvania, Analysis of the mechanisms that maintain intestinal regulatory T cells
• Warakorn Kulalert, NIH, Functional tuning of commensal-specific lymphocytes by nociceptive sensory neurons

Chair

• Jie Sun, Univ. of Virginia

Speakers

• Etienne Humblin, Icahn Sch. of Med. at Mount Sinai, CD28 signaling strength regulates the cell fate of TCF-1+ PD-1+ CD8 T cells
• Michael Battaglia, Univ. at Buffalo Sch. of Med. and BioMed. Sci., Ets1 regulates production of dendritic epidermal T cells (DETC) and cooperates with IL17Ra signaling to regulate immune responses to Staphylococcal skin infection
• Thomas Riffelmacher, La Jolla Inst. for Immunology, Metabolic fuel choices control MAIT cell functions at homeostasis and after infection
• Timofey Karginov, UConn Hlth., Optimal CD8⁺ T cell effector function requires costimulation-induced RNA-binding proteins that reprogram the transcript isoform landscape
• Eshana Mukhopadhyay, Cincinnati Children’s Hosp. Med. Ctr., A role for a DEAD box RNA helicase in natural killer cells
• Mark Elliott Williams, Emory Univ. Sch. of Med., Lineage analysis defines subpopulations of human lung tissue-resident memory CD8+ T cells
• Reed M. Hawkins, Oregon Hlth. and Sci. Univ., Androgen receptor regulation of CD8 T cell immune responses
• Connie Krawczyk, Van Andel Inst., The sexually dimorphic histone demethylase promotes optimal T cell responses during infection

Chairs

• Kathryn A. Knoop, Mayo Clin.
• Michael A. Silverman, Children’s Hosp. of Philadelphia

Speakers

• Michael A. Silverman, Children’s Hosp. of Philadelphia, Arresting microbiome development limits immune system maturation and resistance to infection
• Katherine Z. Sanidad, Weill Cornell Med., Gut microbiome regulates serotonin production in the neonatal intestine to promote immune tolerance in early life
• Mohammed Amir, Weill Cornell Med., Gut microbiota-reactive IgG regulates gut microbiota development and immunity against enteric pathogens in early life
• Kara G. Greenfield, Mayo Clin., Maternally derived epidermal growth factor mediates protection in neonates from opportunistic intestinal pathogens.
• Ellen Merrick Schill, Washington Univ. in St Louis Sch. of Med., Neonatal antibiotic exposure alters intestinal macrophage frequency and polarization
• Elizabeth Managlia, Ann & Robert H. Lurie Children’s Hosp. of Chicago, CD206⁺MHCII^– macrophages present in the neonatal but not adult intestine do not derive from LysM monocytes and are decreased in experimental Necrotizing Enterocolitis
• Julia A. Brown, Weill Cornell Med. Col., The preterm infant microbiome impairs lung immune responses to respiratory syncytial virus infection

Chairs

• Yuan He, Wayne State Univ. Sch. of Med.
• Jian Zhang, Univ. of Iowa

Speakers

• Yilei Ma, Univ. of Iowa, E-Syt1 ubiquitination by Nedd4 limits the caspase-11-mediated non-canonical inflammasome and endotoxemia
• Yuan He, Wayne State Univ., Molecular basis for NEK7-mediated NLRP3 inflammasome activation
• Chi Gidley Weindel, Texas A&M Univ., Col. of Med., Gasdermin D promotes hyperinflammation by triggering necroptosis in the presence of mitochondrial stress
• Swathy Ollikara Vasudevan, UConn Hlth., A TLR4-independent critical role for CD14 in intracellular LPS sensing
• Matthew R. Rice, Feinstein Inst. for Med. Res., STK25 functions as an IRF5 kinase to promote TLR7/8-mediated inflammation
• Nayeon Son, Missouri State Univ., Identification of a novel protein interactions that elucidates the mechanism of hydatidiform molar pregnancies in women with NLRP2 and NLRP7 mutations
• Jamie L. Shirley, Univ. of Colorado Anschutz Med. Campus, PD-L1 back signaling manipulates IL-6 signaling to coordinate innate immune responses

Chairs

• Robert Welner, Univ. of Alabama at Birmingham
• Murad R. Mamedov, Univ. of California, San Francisco

Speakers

• Valeriya Kuznetsova, Univ. of Alabama at Birmingham, Perturbed function of natural killer cells by inflammatory cytokines in acute (AML) and chronic (CML) myeloid leukemias
• Sylvia M. Cruz, Univ. of California Davis Med. Ctr., Characterization of the tumor immune microenvironment in soft tissue sarcoma patients undergoing surgery
• Monica Cho,Univ. of Wisconsin-Madison, CD155 axis modulation promotes natural killer cell-mediated graft-versus-tumor effects against osteosarcoma
• Xia Liu, St. Louis Univ., The fate and function of NK cells in the suppressive tumor microenvironment
• Narendiran Rajasekaran, Northern Arizona Univ., Assembly and localization of extracellular matrix protein fibronectin modulates Natural killer cell infiltration in tumor spheroids
• Clemence Riffard, INSERM, LTi-like type 3 innate lymphoid cells are associated with the transient induction of tertiary lymphoid structures in inflamed pulmonary tissue
• Murad R. Mamedov, Univ. of California, San Francisco, Genome-wide CRISPR screens reveal metabolic and transcriptional regulation of BTN3A and cancer susceptibility to VγVδ2 T cell targeting

Chairs

• Evan Lind, Oregon Hlth. and Sci. Univ.
• Kenneth Murphy, Washington Univ. in St Louis Sch. of Medicine

Speakers

• Briaunna M.N. Minor, Univ. of Rochester Med. Ctr., Estradiol effects on polymorphonuclear cell production and actions contribute to estrogen-mediated lymphangioleiomyomatosis (LAM) progression
• Stacy K. Thomas, Perelman Sch. of Med., Univ. of Pennsylvania, Liver macrophage subsets differentially regulate metastasis in pancreatic cancer
• Irene Saha, Cincinnati Children’s Hosp. and Med. Ctr., The B cell adapter for PI3K (BCAP) promotes M2 macrophage phenotype and safeguards tumors from immune surveillance
• David J. Friedman, Mayo Clin., Enhanced anti-tumor immunity in ST8Sia6 knockout mice
• Jiaying Zheng, Mayo Clin. Grad. Sch. of BioMed. Sci., Hv1 proton channels control myeloid landscape and promote glioma progression
• Patrick A. Flynn, Oregon Hlth. and Sci. Univ., Impact of constitutive FLT3 signaling on dendritic cell development and function in a genetically-engineered mouse model of Acute Myeloid Leukemia
• Renee Wu, Washington Univ. in St Louis Sch. of Med., Mechanisms of CD40-dependent cDC1 licensing beyond co-stimulation

Chairs

• Fayyez Sutterwala, Cedars-Sinai Med. Center
• Naeha Subramanian, Univ. of Washington

Speakers

• Christopher Michael Horn, Univ. of Nebraska Med. Ctr., Glycolysis is critical for granulocytic myeloid-derived suppressor cell (G-MDSC) activity during Staphylococcus aureus biofilm infection
• Maria J. Gonzalez Orozco, Univ. of Texas Med. Br. at Galveston, The E3-ligase TRIM7 acts as an antiviral factor by ubiquitinating the SARS-CoV-2 membrane protein to limit apoptosis and virus replication
• Jacob S. Yount, Ohio State Univ., Interferon-induced transmembrane protein 3 (IFITM3) limits lethality of SARS-CoV-2 in mice
• Smita Kulkarni, Texas Biomed. Res. Inst., Virus-induced long noncoding RNAs regulate SARS-CoV-2 pathogenesis
• Ajay Suresh Akhade, Inst. for Systems Bio., Seattle, A non-canonical role of caspase-1 in regulating bacterial physiology and antimicrobial resistance
• Jerod A. Skyberg, Univ. of Missouri-Columbia, Nucleotide receptors mediate protection against neonatal sepsis and meningitis caused by alpha-hemolysin expressing Escherichia coli K1
• Juselyn D. Tupik, Virginia-Maryland Col. of Vet. Med., The Goldilocks Conundrum: The protective and adverse roles of immunoregulation by NOD-like receptors (NLRs) during brucellosis
• Suman Gupta, Cedars Sinai Med. Ctr., Leptospira spp. are a potent activator of Type I IFN responses via the cGAS-STING pathway

Chairs

• Mark Kaplan, Indiana Univ. Sch. of Med.
• Adrian Piliponsky, Seattle Children’s Res. Inst.

Speakers

• Lauren A. Hesser, Univ. of Chicago, Developing a synbiotic biotherapy to prevent allergic responses to food
• Nada Salem Alakhras, Indiana Univ. Sch. of Med., Covalent heterobivalent inhibitor effectively inhibits anaphylaxis to peanut allergen in a humanized mouse model
• Clinton B. Mathias, Western New England Univ., Interleukin-10 enhances IL-33-mediated MC activation and modulates the development of food allergy
• Irina Miralda Molina, Seattle Children’s Res. Inst., Ligation of Siglec- 9 inhibits FcεRI-dependent mediator release from human mast cells
• Tamara Salloum, Brigham and Women’s Hosp. and Harvard Med. Sch., Transcriptional profiling unveils the heterogeneity of constitutive and inducible mast cells in inflammation and homeostasis
• Adam James Moeser, Michigan State Univ., Androgen receptor deficiency eliminates sex differences in mast cells
• Chang-hyun Kim, Vigencell Inc., Immunomodulatory effects of human myeloid-derived suppressor cells expanded from cord blood on dermatophagoides farinae-induced atopic dermatitis in NC/Nga mice
• Brandon Lee, MIT, Novel association of lyme disease, age, and atopic dermatitis

Chairs

• Ziaur Rahman, Pennsylvania State Univ. Col. of Med.
• Edwin Wan, West Virginia Univ.

Speakers

• Ivy L. Debreceni, Univ. of Iowa, IL-27 signaling contributes to pathogenic T cells in a mouse model of Sjögren’s
• Gabriel Arellano,Northwestern Univ., Interferon-gamma controls pathogenic T-helper 17 and B cells in a new Aquaporin-4 induced experimental autoimmune encephalomyelitis
• Tse-Hua Tan, Natl. Hlth. Res. Inst., MAP4K3/GLK is a novel therapeutic target for IL-17A-mediated autoimmune diseases
• Kelly Lynn Monaghan, West Virginia Univ., Sch. of Med., Tetramerization of STAT5 promotes autoimmune-mediated neuroinflammation
• Mianmian Yin, Univ. of California, San Francisco, Development of uveitis in a mouse model of spontaneous autoimmunity correlates with frequency of autoantigen-specific regulatory T cells
• Seung-Chul Choi, Univ. of Florida, Homeodomain protein Pbx1 regulates regulatory T cell development, stability and suppressive function
• Ulus Atasoy, Michigan Med. at Univ. of Michigan, Treg-specific ablation of HuR results in systemic autoimmunity associated with decreased TLR4 activation and IL-1β production
• Sarah Pasquin, Université de Montréal, Canada, Investigating immune tolerance: characterization of immunoregulatory DN T cells