Sunday, May 8, 2022
All listings subject to change.
Sunday, May 8, 2022 8:00 AM – 11:30 AM Portland Ballroom 252–253
Major Symposium C
Sex Differences in the Immune Response
Chairs
- Sabra L. Klein, Johns Hopkins Bloomberg Sch. of Pub. Hlth.
- Shannon E. Dunn, Univ. of Toronto, Canada
Speakers
- Sabra L. Klein, Johns Hopkins Bloomberg Sch. of Pub. Hlth. , SeXX differences in immunity to influenza and SARS-CoV-2
- Shannon E. Dunn, Univ. of Toronto, Canada, Sex differences in the effect of obesity on T helper 1 immunity
- Dawn C. Newcomb, Vanderbilt Univ. Med. Ctr., Sex hormones regulate allergic airway inflammation in asthma
- Jun R. Huh, Harvard Med. Sch., Pregnancy plays a major role in dictating viral-induced immune responses
- Bérénice A. Benayoun, Univ. of Southern California, Lifelong sex differences in neutrophil phenotypes
- Kanakadurga Singer, Univ. of Michigan, Sex differences in obesity-induced meta-inflammation
Sunday, May 8, 2022 8:00 AM – 11:30 AM Portland Ballroom 254–255
Major Symposium D
Maintaining Tissue Homeostasis during Initiation and Resolution of Inflammation
Chairs
- Daniel J. Campbell, Benaroya Res. Inst.
- Keke C. Fairfax, Univ. of Utah
Speakers
- Keke C. Fairfax, Univ. of Utah, Influence of bone marrow inflammation on tissue immunity
- Sarah L. Gaffen, Univ. of Pittsburgh, IL-17 signaling crosstalk during inflammation
- Gudrun F. Debes, Thomas Jefferson Univ., Skin regulatory B cells: homing and function
- Brian S. Kim, Icahn Sch. of Med. at Mount Sinai, Itch paradigms: neuroimmune regulation of somatosensation
- Daniel J. Campbell, Benaroya Res. Inst., Manipulating regulatory T cell activity in tissues to treat autoimmunity
Sunday, May 8, 2022 8:00 AM – 10:00 AM
Block Symposia
- B Cell and T Cell Helper Responses during Viral Infections
Oregon Ballroom 202
- Big Data: The Key to Unlocking Immune Mediated Mechanisms of Tumor Progression and Therapy Response
Room B113–116
- Infection and Disease
Oregon Ballroom 201
- Molecular Mechanisms of Inflammation
Room B117–119
- Mucosal Innate Immune Cells
Room A105–106
- T Cell Effector Generation and Function
Room C123–124
Sunday, May 8, 2022 8:00 AM – 10:00 AM Room A107–109
NextGen Transformative Immunologic Therapies for Human Disease
Sponsored by the AAI Clinical Immunology Committee
Chairs
- Jennifer H. Anolik, Univ. of Rochester Med. Ctr., AAI Clinical Immunology Committee Chair
- Erica L. Stone, GigaGen
Speakers
- Jeffrey S. Miller, Univ. of Minnesota, Twin Cities, The next generation of NK cell therapeutics to treat cancer
- Stephanie K. Dougan, Dana-Farber Cancer Inst., Inducing and sustaining tumor-specific memory CD8+ T cells
- Samik Basu, Cabaletta Bio, Adoptive immunotherapy for MuSK subtype myasthenia gravis
- S. Alice Long, Benaroya Res. Inst., Treg modulation by IL-2 mutein therapy
Understanding the underlying mechanisms of pathology for disease states has allowed for both the manipulation and targeting of specific aspects of the immune response to alleviate, or in some instances cure, immune and non-immune mediated diseases. But how does basic immunology research evolve into potential therapies, and how do those therapies get developed? And what are the new, up-and-coming therapies currently in development? In this session, four speakers will highlight therapies that are in the pipeline for clinical use and tell their stories, from target identification to their use in clinical trials.
Sunday, May 8, 2022 8:00 AM – 10:00 AM Oregon Ballroom 204
National Institute on Aging (NIA), NIH Symposium
Role of the Immune System in Neuroinflammation and Neurodegenerative Diseases
Chairs
- Rebecca Fuldner, NIA, NIH
- Katrin I. Andreasson, Stanford Med.
Speakers
- Jonathan Kipnis, Washington Univ. Sch. of Med. in St. Louis, Surprising immune activities at brain’s borders
- Katrin I. Andreasson, Stanford Med., Immune-metabolic mechanisms of cognitive decline in aging
- Adrian Liston, Cambridge Univ., United Kingdom, Using brain regulatory T cells to prevent neurodegeneration
- Elizabeth M. Bradshaw, Columbia Univ., Genetics of late-onset Alzheimer’s disease: a microglia story
Sunday, May 8, 2022 10:00 AM – 10:45 AM Exhibit Hall, Workshop Room 1
Exhibitor Workshop: NanoString Technol.
Advances in Spatial Immunology
Speakers
- Elizabeth Schneider, Ph.D., Spatial Biology: See the Immune Microenvironment in a Whole New Light
- Jacob D. Estes, Ph.D., Prof., Vaccine & Gene Therapy Inst., Affiliate Prof., Dept. of Molecular Microbiology & Immunology, Chief, Div. of Pathobiology and Immunology, Oregon National Primate Res. Ctr. Oregon Hlth. & Sci. Univ., Characterizing and Eliminating the Follicular Dendritic Cell HIV Reservoir
HIV cannot be eradicated by antiretroviral therapies (ART) alone. A comprehensive understanding of all HIV reservoirs with the potential to reignite systemic infection after discontinuation of ART is key to realizing any HIV cure. See how Dr. Estes and his colleagues uncover novel insights into the impact of ART treatment on viral reservoirs in the context of their tissue microenvironments and cellular immune neighborhoods in the non-human primate models using comprehensive spatial profiling strategies. These methods have improved their understanding of the unique FDC-HIV reservoir and provide insights for devising effective treatment approaches as part of a combinatorial HIV cure strategy.
Sunday, May 8, 2022 10:00 AM – 10:45 AM Exhibit Hall, Workshop Room 2
Exhibitor Workshop: Luminex, A DiaSorin Company
Bead-based Multiplex Assays for Malaria Epidemiological Estimates and Immunological Studies
Speaker
- Eric Rogier, Ph.D., M.P.H., Microbiologist, CDC
Malaria is caused by Plasmodium infection and is a major public health burden in many tropical areas of the world. As malaria may be asymptomatic and health facility reporting unreliable, gaining accurate epidemiological estimates can be difficult. Multiplexing data collection for Plasmodium proteins and IgG against parasite antigens provides valuable datasets to better understand the different species and transmission, identify areas for resource allocation, and track trends over time. As dozens of malaria serological targets have been identified, bead-based multiplexing allows simultaneous collection of IgG data within the same assay well for immunoprofiling purposes.
Sunday, May 8, 2022 10:00 AM – 10:45 AM Exhibit Hall, Workshop Room 3
Exhibitor Workshop: 10x Genomics
High-Throughput Cell and Repertoire Profiling at Single-Cell Resolution
Speaker
- Rea Dabelic, Ph.D., Sr. Manager, Market Development, Immunology
Immune cells are multidimensional. While access to the transcriptome of individual cells from a heterogeneous blood or tumor sample can reveal critical information about cell identity and state, there are many more dimensions of immune cell biology to understand and leverage in the effort to identify novel antibodies, develop improved immunotherapies, and advance human health. Now, capture multiple dimensions of immune cell biology, from cell surface proteins and antigen specificity, all at single-cell resolution, with multiomic cytometry.
Sunday, May 8, 2022 10:15 AM – 11:15 AM Room B117–119
Interviewing for a Job
Chair
- Mary T. Litzinger, AAI
Speaker
- Derek J. Haseltine, Hertz Fndn.
This session will focus on tips and techniques to help you successfully navigate the interview process. Emphasis will be on how to present yourself in the best possible light. You will also learn how to respond to unexpected questions. This session is open to anyone but is especially intended for student and postdoctoral attendees.
Sunday, May 8, 2022 10:15 AM – 12:15 PM Room A105–106
Vaccine Acceptance: Lessons from the Past and Tools for the Future
Sponsored by the AAI Committee on Public Affairs
Chair
- Peter E. Jensen, Univ. of Utah Sch. of Med., AAI Committee on Public Affairs Chair
Speakers
- Richard M. Carpiano, Professor of Public Policy, Univ. of California, Riverside, Why people vaccinate: social, behavioral, and policy considerations
- Akiko Iwasaki, HHMI, Sterling Professor of Immunobiology and of Molecular, Cellular and Developmental Biology, Yale Sch. of Med., Disinformation and information that fuel vaccine hesitancy
Vaccines have long been one of the most effective tools to combat infectious diseases, saving countless lives since the development of the first vaccine against smallpox in the late 18th century. Because of vaccines, smallpox has been eradicated worldwide, polio has been eliminated in the United States, and other deadly diseases including rubella, pertussis, and measles are now preventable. Despite this evidence, concerns about the safety or efficacy of vaccines persist. The problem of waning vaccine acceptance has only been exacerbated by the COVID-19 pandemic. Although scientists have developed remarkably safe and effective vaccines against COVID-19 in record time, and several have been approved by the U.S. Food and Drug Administration, far too many eligible Americans remain unvaccinated. Concerns about vaccine safety and efficacy, widespread misinformation and disinformation about vaccines, and the politicization of public health recommendations have hampered the acceptance of these lifesaving tools, posing an increasingly serious threat to individual lives and global public health.
This session will feature experts who will discuss lessons learned about vaccine acceptance, the challenges that lie ahead, and how we as members of the broader biomedical research community can effectively communicate with the public. A question-and-answer period will follow the formal presentations.
Sunday, May 8, 2022 10:15 AM – 12:15 PM Room A107–109
Canadian Society for Immunology (CSI) Symposium
Mesenchymal—Immune Crosstalk in Fibrotic Disease
Chairs
- Sonya A. MacParland, Univ. of Toronto, Canada
- Simon A. Hirota, Univ. of Calgary, Canada
Speakers
- Simon A. Hirota, Univ. of Calgary, Canada, Microbial metabolite sensing shapes the mesenchyme to restrain intestinal inflammation and fibrosis
- Sonya A. MacParland, Univ. of Toronto, Canada, Liver macrophage populations in fibrosis and tissue regeneration
- Carolyn J. Baglole, McGill Univ., Canada, Aryl hydrocarbon receptor and fibroblast–neutrophil interactions in chronic obstructive pulmonary disease
- Kelly M. McNagny, Univ. of British Columbia, Canada, Innate lymphoid cells in tissue fibrosis
Sunday, May 8, 2022 10:15 AM – 12:15 PM
Block Symposia
- Primary Immune Deficiency and Immune Dysregulation
Oregon Ballroom 201
- Technological Innovations in Immunology II
Oregon Ballroom 204
- Tissue-Resident Memory T Cells (Trm) in Cancer
Oregon Ballroom 202
Sunday, May 8, 2022 10:15 AM – 12:15 PM Room B110–112
International Complement Society (ICS) Symposium
Complement: The Road Less Traveled
Chairs
- Viviana P. Ferreira, Univ. of Toledo
- Michael V. Holers, Univ. of Colorado Sch. of Med.
Speakers
- Michael V. Holers, Univ. of Colorado, Sch. of Med., Stage- and context-dependent roles for complement in rheumatoid arthritis evolution
- Jessy J. Alexander, Univ. at Buffalo, SUNY, Intracellular complement control and kidney disease
- Jeanne T. Paz, Inst. of Neurological Dis. and Univ. of California, San Francisco, New roles for complement during brain injury
- Mihalis S. Lionakis, NIAID, NIH, New insights into complement’s role in the control of fungal disease
Sunday, May 8, 2022 11:15 AM – 12:00 PM Exhibit Hall, Workshop Room 3
Exhibitor Workshop: BD Biosciences
Deep Science Seminar: High-dimensional Biology for Biomarker Discovery and Functional Characterization of Novel Cell Subsets
Speaker
- Robert Balderas, VP Biological Sci.
As technologies in our industry advance in complexity, speed, sensitivity and ease of use, the opportunity to use multiple approaches to answer high-dimensional biological questions is changing and expanding our knowledge of immunology. This presentation will highlight how the combined use of high-parameter analytical flow cytometry and advanced single-cell multiomic tools (proteomic and genomic) can help define functional murine NK cell subsets.
Sunday, May 8, 2022 11:15 AM – 12:00 PM Exhibit Hall, Workshop Room 1
Exhibitor Workshop: Lunaphore Technologies
Turn a Standard Immunofluorescence Assay into Spatial Proteomics
Speaker
- James Denegre, Ph.D., Field Application Scientist
Lunaphore brings new ways of utilizing any standard reagents to perform multiplex immunofluorescence assays, empowering researchers with a slide-in data-out approach. In this workshop, we will present our recent advancements highlighting COMET, a walk-away staining and imaging solution that enables single-cell analysis, up to 40 biomarkers on the same slide. Attendees will also check and discuss data on the impact of using this ground-breaking technology to minimize assay development time and move faster in deciphering the immune microenvironment.
Sunday, May 8, 2022 11:15 AM – 12:00 PM Exhibit Hall, Workshop Room 2
Exhibitor Workshop: Akadeum Life Sci.
Buoyancy-Activated Cell Sorting Enables More Efficient Leukopak Processing and High-Quality Cell Isolation
Speakers
- Jon Roussey, Ph.D., Associate Director of R&D
- Ichwaku Rastogi, Res. Asst., Univ. of Wisconsin
Buoyancy Activated Cell Sorting (BACS™) Microbubbles from Akadeum Life Sciences offers a gentle and effective flotation-based cell isolation platform that is unbound from the constraints of magnets and columns. At this workshop, we will present two examples of the advantages that BACS have over conventional cell isolation methods. First, we will demonstrate how microbubbles eliminate volume limitations and pre-processing steps for the isolation of T cells from leukopaks. Then, University of Wisconsin researcher Ichwaku Rastogi will discuss how microbubble-based isolation of B cells enabled recent findings identifying B cells as primary APCs following passive uptake of plasmid DNA. I.Rastogi receives research grants, salary support, or in-kind support from Akadeum Life Sciences.
Sunday, May 8, 2022 12:30 PM – 2:30 PM Room A107–109
NIH Grants Workshop: Demystifying the Grant Application Submission, Review, and Funding Processes
Chair
- Deborah L. Hodge, NIAID, NIH
Panelists
- Joseph J. Breen, NIAID, NIH
- Deborah L. Hodge, NIAID, NIH
- Michelle M. Arnold, CSR, NIH
- Audrey Lau, CSR, NIH
This workshop will provide participants with an overview of NIH grant submission, assignment, review, and funding opportunities. Emphasis will be given to identification of the most appropriate funding agencies and mechanisms available through NIH, how to make an application “reviewer friendly,” and other strategies that contribute to applications that succeed in obtaining research funding.
The workshop will also provide information on how to understand the peer review system, which is essential to competing successfully for funding, with a focus on recent changes to the review process. NIH review and program staff will provide a broad array of expertise and encourage questions from seminar participants. This workshop is open to anyone interested in learning more about preparing an NIH grant application and obtaining NIH funding. Trainees and independent investigators are welcome.
Sunday, May 8, 2022 12:30 PM – 2:00 PM Portland Ballroom 251
Careers in Science Lecture and Roundtables
Sponsored by the AAI Education Committee and AAI Committee on the Status of Women
Generously supported by 10x Genomics
Chair
- Laura A. Solt, Scripps Res., AAI Committee on the Status of Women Chair
Speaker
- Gwendalyn J. Randolph, Washington Univ. Sch. of Med. in St. Louis, Becoming a confident scientist and embracing your authentic self
At this popular session, attendees will have the opportunity to meet with experienced scientists to explore specific career issues important to today's scientists. Gain insights into issues you are confronting in your own career. Topics include international opportunities in science, succeeding in graduate school, tips on grant writing, considerations for scientists in M.D.-Ph.D. careers, and exciting careers beyond the bench. Topics include building productive mentor/mentee relationships; overcoming self-doubt; and tackling gender biases in recruitment, research, and leadership; and navigating work/life issues, such as balancing careers with family and transitioning from specific career stages, which may be relevant to any work environment (academic research, biotech industry, governmental agencies, non-profit). Don’t miss this great opportunity!
Discussion Topics and Table Leaders
New PI (mentoring effectively, recruiting students and postdocs, preparing for promotion, early career self-promotion)
- Irene Salinas, Univ. of New Mexico, and Qi Yang, Rutgers Univ.
- Robin Stephens, Univ. of Texas Med. Br., and Isabella Rauch, Oregon Hlth. Sci. Univ.
Succeeding in Graduate School
- Laura Solt, Scripps Res., and Maureen McGargill, St. Jude Children's Res. Hosp.
Graduate Student to Postdoc
- Daniel Abate-Daga, Moffitt Cancer Ctr., and Mireia Guerau-de-Arellano, The Ohio State Univ. Col. of Med.
- Juliet Morrison, Univ. of California, Riverside, and Natalie Steinel, Univ. of Massachusetts, Lowell
Postdoc to PI
- Angela Rasmussen, Univ. of Saskatchewan, Canada, and Jose Guevara, Moffit Cancer Ctr.
- Gianna Hammer, Duke Univ. Sch. of Med., and Lisa Denzin, Rutgers Univ.
Work/Life Balance
- Shari Pilon-Thomas, Moffit Cancer Ctr., and Laura Santambrogio, Englander Inst. of Precision Med. and Weill Cornell Med.
Building Networking Skills
- Yina Huang, Geisel Sch. of Med. at Dartmouth, and Jennifer Grier, Univ. of South Carolina Sch. or Med., Greenville
Biotech and Industry
- Rea Dabelic, 10x Genomics, and Sadiye Rieder, Horizon Therapeut.
- Kiyomi Komori, Arena Pharma., and Agata Bartczak, Horizon Therapeut.
- Yue Liu, Ab Studio, and Louis Gonzalez, Shattuck Labs
- Shaoquan Ji, BioTimes, and Karsten Sauer, Repertoire Immune Medicines
- Aliyah Weinstein, Taconic, and Christie Mortales, Neoleukin Therapeut.
- Seng-Lai (Thomas) Tan, Immunitas Therapeut., and Yibing Wang, BeiGene (Shanghai) Res.
- Dwight Morrow, Rubius Therapeut., and Bo Lin, Nexcelom Biosci.
Embracing Your Authentic Self and Becoming a Confident Scientist
- Gwen Randolph, Washington Univ. Sch. of Med. in St. Louis, and Sarah Gaffen, Univ. of Pittsburgh
Tackling Gender Biases in Recruitment, Research, and Leadership
- Dorina Avram, Moffitt Cancer Ctr., and Marion Pepper, Univ. of Washington
Careers in Government Agencies
- Swinburne Augustine, Envrn. Protection Agcy., and Michelle Robillard, Envrn. Protection Agcy.
Scientific Publishing
- Jose Conejo-Garcia, Moffitt Cancer Ctr., and Courtney Malo, Sci. Translational Med.
Opportunities for Scientists in Non-profits/Foundations
- E’Lissa Flores, Hlth. and Envrn.Sci. Inst.
Careers in Science Policy
- Lauren Gross, AAI
Grant Writing for PIs
- Meera Nair, Univ. of California, Riverside, and Jie Sun, Univ. of Virginia Sch. of Med.
Grant Writing: Fellowships
- Paulo Rodriguez, Moffit Cancer Ctr., and Melissa Brown, Northwestern Univ. Feinberg Sch. of Med.
Research from M.D.-Ph.D. Perspective / The Physician Scientist
- Maureen Su, Univ. of California, Los Angeles
Careers in Veterinary Immunology
- Mercedes Gonzalez-Juarrero, Colorado State Univ. Col. of Vet. Med. and Biomed. Sci,and Brina Lopez, Midwestern Univ.
International Opportunities
- Weishan Huang, Louisiana State Univ. Sch. of Vet. Med., and Henrique Borges da Silva, Mayo Clin.
- Damian Maseda, Univ. of Pennsylvania, and Jacques Robert, Univ. of Rochester Med. Ctrr.
Building Productive Mentor/Mentee Relationships
- Virginia Shapiro, Mayo Clin., and Edith Porter, California State Univ., Los Angeles
Balancing Teaching Responsibilities with Research NEW!
- Julie Jameson, California State Univ., San Marcos, and Michelle Swanson-Mungerson, Midwestern Univ.
How to Negotiate for Better Self-promotion
- Keke Fairfax, Univ. of Utah Sch. of Med., and Henrique Serezani, Vanderbilt Univ. Med. Ctr.
Sunday, May 8, 2022 12:30 PM – 2:30 PM Room C123–124
Scientific Communication in a Fast-Paced World
Sponsored by the AAI Publications Committee
Chairs
- Daniel J. Campbell, Benaroya Res. Inst., AAI Publications Committee Chair
- Eugene M. Oltz, The Ohio State Univ. Col. of Med., Editor-in-Chief, The Journal of Immunology
Speakers
- Laurie E. Harrington, Univ. of Alabama at Birmingham, Writing manuscripts with trainees
- Jessica A. Hamerman, Benaroya Res. Inst., Responding to reviewers
- Mark H. Kaplan, Indiana Univ. Sch. of Med., Editor-in-Chief, ImmunoHorizons, Why you should publish in ImmunoHorizons—and The JI too!
This session will feature a moderated panel discussion on key topics in publishing: open access, fairness in peer review, preprints, and more!
Sunday, May 8, 2022 12:30 PM – 2:30 PM
Block Symposia
- The Impact of the Commensal Microbiome on Cancer Progression and Therapy Response
Room B113-116
- Innate Immunity to Viral Infection
Oregon Ballroom 203
- Innate Signaling, Microbiome, and Metabolism in Autoimmunity
Room B110–112
- Neuronal and Central Nervous System Immunity
Room B117–119
- Vaccines and Immunity against Bacteria and Parasites
Oregon Ballroom 202
Sunday, May 8, 2022 12:30 PM – 2:30 PM Room A105–106
American Society of Transplantation (AST) Symposium
Cutting-Edge Research in Transplantation Tolerance, Rejection, and Infection
Chairs
- Andrew D. Wells, Univ. of Pennsylvania Perelman Sch. of Med.
- Anita S. Chong, Univ. of Chicago
Speakers
- Xunrong Luo, Duke Univ. Sch. of Med., Single-cell transcriptomics of kidney transplants reveals a myeloid cell pathway for transplant rejection
- Andrew D. Wells, Univ. of Pennsylvania Perelman Sch. of Med., Molecular and genetic mechanisms regulating T cell tolerance
- Paige M. Porrett, Univ. of Alabama at Birmingham, Exhaustion circuits program maternal CD8+ T cell hypofunction in pregnancy and transplantation
- Jonathan S. Maltzman, Stanford Univ., Memory inflation after CMV
Sunday, May 8, 2022 12:30 PM – 1:15 PM Exhibit Hall, Workshop Room 1
Exhibitor Workshop: FlowJo, LLC
Vidi Vici Idolum: A Guide to Conquering High-dimension Data from Clean-up to Trajectory Analysis
Speaker
- Jack Panopoulos, Ph. D., Application Scientist
A diverse repertoire of algorithmic tools is needed to identify novel phenotypes, functional states, and disease correlates from high-dimensional data. In this tutorial we will review the primary classes of algorithm applicable to cytometric data, and then demonstrate a high-dimensional workflow using an exemplar from each class. We will then push the traditional bounds via a trajectory analysis algorithm, TrackSOM. The nature of the cytometric data tends to confine analysis to a ‘snapshot’ of cellular dynamics. Trajectory analysis follows population dynamics over multiple time points, adding a layer of functional analysis that was previously difficult to ascertain.
Sunday, May 8, 2022 12:30 PM – 1:15 PM Exhibit Hall, Workshop Room 2
Exhibitor Workshop: STEMCELL Technol., Inc.
Tools for Fundamental & Translational NK Cell Research
Speakers
- Sneha Balani, Ph.D., Product Manager, Immunology
- Tim Le Fevre, B.Sc., Scientist
Natural killer (NK) cells are gaining popularity as a therapeutic tool for their unique ability to recognize and kill virus-infected and cancer cells without prior immune sensitization. Generating these cells in therapeutically relevant numbers continues to be a major challenge in the field. In this workshop, we will discuss reagents for cell isolation and generating NK cells from stem cells. We will also feature a new, streamlined culture system that enables feeder- and serum-free expansion of functional NK cells with high yields, providing a complete workflow solution for NK cell research.
Sunday, May 8, 2022 12:30 PM – 1:15 PM Exhibit Hall, Workshop Room 3
Exhibitor Workshop: Emulate
Modeling Inflammatory Immune Cell Recruitment and Response with the Colon Intestine-Chip
Speaker
- Christopher Carman, Ph.D., Director of Immunology
Recruitment of circulating immune cells into tissues is a key driver of complex human diseases, such as inflammatory bowel disease (IBD). To model IBD, we perfused peripheral blood mononuclear cells (PBMCs) through the Emulate Colon Intestine-Chip’s vascular channel. In the presence of priming cytokines/chemokines, we observed selective migration of ‘gut-specific' (α4β7+) PBMCs into the epithelial channel where they secreted IBD cytokines (e.g. INFγ, IL1 β, IL18) and induced barrier disruption. These events were abrogated by clinically relevant α4β7+ targeting drugs, suggesting the model may provide a more human-relevant platform for IBD drug development.
Sunday, May 8, 2022 1:45 PM – 2:30 PM Exhibit Hall, Workshop Room 1
Exhibitor Workshop: BioLegend
Cutting-Edge Technology for Deep Characterization of Viral and Self-Antigen Peptide-Induced Cellular Immune Responses
Speaker
- Rebecca Nickle, Ph.D., Technical Applications Scientist
Biological processes are complex, and to understand them in a holistic manner, researchers need to use multiple tools and innovative approaches to capture that complexity. As our understanding of cell physiology and pathological conditions advances, the need for more sophisticated technology and applications continues to push the development of integrated solutions. For many years, BioLegend has been at the front of this development, the most recent example being our Universal TotalSeq™ cocktails to enable multiomic protein analysis by sequencing. Here, we combine several of our cutting-edge reagents for a deep characterization of peptide antigen-induced immune responses. We describe and compare the activation, expansion, and specific T cell response against SARS-CoV-2 spike protein, myelin basic protein, and melanocyte-A immunodominant peptides. T helper subset characterization was achieved with LEGENDplex™ soluble analyte analysis, intracellular and extracellular protein analysis with spectral cytometry, and simultaneous single-cell protein and RNA analysis with our TotalSeq™-C Universal Cocktail. All together, these data provide a unique and comprehensive characterization of in vitro induced viral- and self-peptide specific T cells, revealing similarities and differences in the immune response against viral pathogens and autoimmune diseases.
Sunday, May 8, 2022 1:45 PM – 2:30 PM Exhibit Hall, Workshop Room 2
Exhibitor Workshop: Thermo Fisher Scientific
High-Throughput Gene and Protein Analysis Using Luminex xMAP-based Assays: Integrated and Comprehensive Workflows, from Sample Prep to Data Analysis
Speaker
- Riddhi Sood, Field Application Scientist
In this workshop you will learn how to analyze your precious samples for protein and gene expression using a highly efficient and high-throughput workflow. Starting from experimental setup to sample prep and running the assays all the way to data generation and analysis, we demonstrate our powerful options. An imaginary tour through a cell culture screening experiment will teach you how to measure up to 65 proteins and 80 genes in every well of a 96- or 384-well plate. Our extensive portfolio of immunoassays consists of single analyte assays like ELISA and Prequantum and multiplex Luminex-based assays (Invitrogen QuantiGene Plex and ProcartaPlex for multiplex gene expression and protein analysis).
Sunday, May 8, 2022 1:45 PM – 2:30 PM Exhibit Hall, Workshop Room 3
Exhibitor Workshop: Akoya Biosci.
Spatial Phenotyping: A New Paradigm for Unbiased Discovery
Speakers
- Oliver Braubach, Ph.D., Head of Applications, Catalyzing the Spatial Biology Revolution
- Ruan Medrano, Ph.D., Washington Univ. Sch. of Med. in St. Louis, Spatial Insights into Successful Cancer Immunotherapy Via CODEX Profiling
Spatial phenotyping is a transformative spatial biology approach that combines whole-slide imaging at single cell resolution to visualize and quantitate biomarker expression. By revealing how cells interact and organize, it provides invaluable insights into immune system architecture and function in the context of healthy and diseased tissue landscapes. Join us to learn how you can apply spatial phenotyping in your work—from early discovery to translational and clinical research. We’ll preview the latest data from the PhenoCycler™-Fusion system, the fastest single-cell spatial biology solution, and discuss groundbreaking new techniques for high-dimensional profiling of spatial data.
Sunday, May 8, 2022 2:30 PM – 3:45 PM Exhibit Hall
Poster Session
- Antigen Presentation and Tumor Microenvironment
- Antigen Processing and Presentation
- Autoantigen Identification, Autoantigen Specificity, and Central Tolerance
- Autoimmunity
- B and T Cell Development
- CD8+ T Cells in Cancer
- Engineering of T Cell Based Therapies
- From Sharks, Fish, and Frogs to Mammals: Fascinating Immunological Discoveries
- Immunoregulation—Infection and Immunity
- Immunology Education
- The Impact of the Commensal Microbiome on Cancer Progression and Therapy Response
- Innate and Adaptive Immunity to SARS-CoV-2
- Innate and Adaptive Immunity to Viruses I
- The Ins and Outs of Airway Inflammation
- Mechanisms of Resistance to Therapy
- Microbiota and Epithelial Interactions
- Molecular and Cellular Control of Humoral Immunity
- Molecular, Metabolic, and Epigenetic Regulation of Innate Immunity and Inflammation
- Mucosal Immune Regulatory Mechanisms
- Non-Immune Therapies in Cancer
- Regulation of B and T Cells in Autoimmune Diseases
- Technological Innovations in Immunology I
- They Come and They Go: A Leukocyte Migration Extravaganza
- Tissue Immunity at Barrier Sites
- Tumor Immunotherapy (TM1)
Sunday, May 8, 2022 2:30 PM – 3:45 PM Exhibit Hall
Sunday in the AAI Booth
- The Journal of Immunology Editor-in-Chief Eugene M. Oltz
- Clinical Immunology Committee
Sunday, May 8, 2022 3:45 PM – 5:15 PM Room B117–119
AAI Special Session
NIH Policy for Data Management and Sharing: Are you Ready?
Chair
- Cathryn R. Nagler, Univ. of Chicago, AAI Program Chair
Speakers
Taunton Paine
Director, Sci. Data Sharing Policy Div., Office of Sci. Policy, NIH
The NIH Policy for Data Management and Sharing: explanation of the policy and the benefit to the research community
Yvette Seger
Director of Sci. Policy, Fed. of the American Soc. for Exptl. Biol. (FASEB)
FASEB DataWorks! A new initiative to support data sharing and re-use
Data are a fundamental component of the research process. Sharing that data is essential to accelerate and enhance research discoveries and to advance research findings. Central to this process, the NIH is responsible for promoting the sharing and management of scientific data to promote reproducibility and translation of research results to advance science, medicine, and public health.
This session will inform the attendees about the facts and details of the NIH Policy for Data Management and Sharing, which goes into place as a requirement for all NIH-funded investigators on January 25, 2023. A special initiative sponsored by FASEB DataWorks! will also be presented. This program has been established to support investigators in navigating the oftentimes confusing open-data landscape and to assist them in designing effective practices for data sharing. The session will end with a question-and-answer opportunity for attendees.
Sunday, May 8, 2022 3:45 PM – 5:45 PM Room B110–112
International Cytokine and Interferon Society (ICIS) Symposium
Rising Stars of Cytokine Biology
Chairs
- Sarah L. Gaffen, Univ. of Pittsburgh
- Rebecca C. Coll, Queen’s Univ. Belfast, United Kingdom
Speakers
- Rebecca C. Coll, Queen’s Univ. Belfast, United Kingdom, Harnessing the power of NLRP3—pharmacological strategies for inhibition and activation of the inflammasome
- Shruti Naik, Grossman Sch. of Med., Immune-epithelial crosstalk in tissue repair
- Fiachra Humphries, Univ. of Massachusetts Chan Med. Sch., Therapeutic modulation of STING
- Jakob von Moltke, Univ. of Washington, Small intestinal tuft cells: sentinels and effectors of type 2 immunity
Sunday, May 8, 2022 3:45 PM – 5:45 PM Room C123–124
Neonatal Immunity and Neuroimmunology
Co-sponsored by the AAI Minority Affairs Committee and Black in Immuno
Chairs
- Michael M. Opata, Appalachian State Univ., AAI Minority Affairs Committee Member
- Dionna W. Williams, Johns Hopkins Univ. Sch. of Med.
Speakers
- Michael M. Opata, Appalachian State Univ., Neonatal immunity to malaria using a mouse model
- Dionna W. Williams, Johns Hopkins Univ. Sch. of Med., Beyond GPCR recycling: β-arrestin as a neuroprotective modulator of innate immune responses
- Olivia Solomon, Univ. of Texas Med. Br., A window into experimental cerebral malaria reveals dynamics of hyper-coagulation, BBB disruption, and microgliosis
- Shevon N. Alexander, Univ. of Texas, Dallas, Sex differences in alcohol-induced behavioral sensitization
- E. Evonne Jean, Univ. of Pennsylvania Perelman Sch. of Med, Understanding the mechanisms of immunity against percutaneous infection by a skin-penetrating helminth
This session will showcase innovative research in neuroimmunology being conducted in laboratories led by prominent Black immunologists. Presentations by first authors of recently published studies in the fast-moving field of neuroimmunology will highlight the work of rising scientists and trainees from historically underrepresented groups. Given the success of these immunologists, these talks implore us to implement pathways that provide supportive and vibrant environments that continue to foster the efforts of these outstanding young investigators.
Sunday, May 8, 2022 3:45 PM – 5:45 PM
Block Symposia
- CD4+ T Cells in Cancer
Room A105–106
- CD8+ T Cell Immunity to Viral Infections
Oregon Ballroom 201
- Therapies for Rheumatic Diseases and Beyond
Oregon Ballroom 202
- Transplant Immunology: Novel Mechanisms and Interventions
Oregon Ballroom 203
- Tumor Microenvironment (TME) I
Room B113–116
- Vaccination and Immunotherapy against COVID-19
Oregon Ballroom 204
Sunday, May 8, 2022 4:30 PM – 5:30 PM Portland Ballroom 252–255
AAI-BioLegend Herzenberg Award Presentation and Lecture
Generously supported by BioLegend
Chair
- Gary A. Koretzky, Cornell Univ. and Weill Cornell Med., AAI President (2021–2022)
Award Recipient
Christopher C. Goodnow
Garvan Inst. of Med. Res., Australia
Autoantibody control: a conceptual journey from B cell functional silencing to immune tolerance checkpoints
AAI President Gary A. Koretzky, AAI Vice President Mark M. Davis, HHMI, Stanford Univ. Sch. of Med., and Leonore A. Herzenberg, Stanford Univ. Sch. of Med., will introduce the awardee and present the award immediately prior to Dr. Goodnow’s lecture.
The AAI-BioLegend Herzenberg Award recognizes outstanding research contributions to the field of immunology in the area of B cell biology.
Sunday, May 8, 2022 6:00 PM – 7:00 PM Portland Ballroom 252–255
AAI-Thermo Fisher Meritorious Career Award Presentation and Lecture
Generously supported by Thermo Fisher Scientific
and the
2022 Distinguished Lecture
Chair
- Gary A. Koretzky, Cornell Univ. and Weill Cornell Med., AAI President (2021–2022)
Award Recipient
Katherine A. Fitzgerald
Univ. of Massachusetts Chan Med. Sch.
Regulation, initiation, and resolution of inflammation
AAI President Gary A. Koretzky and David Piper, Senior Director of Research and Development (Protein and Cell Analysis), Thermo Fisher Scientific, will introduce the awardee and present the award immediately prior to Dr. Fitzgerald’s lecture.
The AAI-Thermo Fisher Meritorious Career Award recognizes a mid-career scientist for outstanding research contributions to the field of immunology.