07Sat

Chair

• Anna Halling Folkmar Andersen, New York Univ. Langone Med. Center

Speakers

• Monika Kizerwetter, Johns Hopkins Univ., Anti-CD123 chimeric antigen receptor natural killer cell therapy to treat acute myeloid leukemia
• Nicholas R. J. Gascoigne, Natl. Univ. of Singapore, Utilizing distinct CAR and TCR signaling to generate enhanced cellular immunotherapy
• Daniel S. Wilkinson, Duke Univ. Med. Ctr., D2C7 CAR: A novel CAR T cell that simultaneously targets wildtype EGFR and its mutant isoform EGFRvIII for treatment of glioma
• Jillian Baker, Univ. of Maryland Sch. of Med., Engineering anti-CD229 CAR T cell selectivity for multiple myeloma
• Xander Gordon Ray Bradeen, Univ. of Colorado Anschutz Med. Campus, Identifying novel epigenetic modifiers that sensitize T cell malignancies to CD8⁺ T cell mediated cytotoxicity by high throughput drug screen
• Royce Ma, Baylor Col. of Med., T cells resist CD5 CAR mediated fratricide by continuously degrading CD5 protein
• Caitlin C. Zebley, St. Jude Children’s Res. Hosp., CD19-CAR T cells develop exhaustion epigenetic programs during a clinical response
• Nayan Jain, Mem. Sloan Kettering Cancer Ctr., SUV39H1 disruption imparts functional persistence to CD28-costimulated human CAR T cells

Chairs

• Connie Krawczyk, Van Andel Inst.
• Sarah Ewald, Univ. of Virginia

Speakers

• Chao Yang, Hosp. for Special Surgery, Costimulation of TLR8 responses by CXCL4 in human monocytes mediated by TBK1-IRF5 signaling and epigenomic remodeling
• Matthew D. Woolard, Louisiana State Univ. Hlth. Sciences Ctr. at Shreveport, Lipin-1 integrates lipid metabolism with macrophage function to promote inflammation resolution
• David Orlando Diaz-Jimenez, NIEHS, NIH, Glucocorticoids suppress NLRP3 Inflammasome activation through transcriptional metabolic reprogramming of IRG-1/ACOD1 in macrophages
• Raza Ali Naqvi, Univ. of Illinois at Chicago, Modulation of myeloid cell functions by long noncoding RNAs RN7SK and HCG11
• Alicer Keendalyn Andrew, Univ. of Georgia, Relationships between inflammation, coagulation, and oxidative stress in malaria-induced pregnancy compromise
• Abhimanyu Abhimanyu, Baylor Col. of Med., Targeting TCA cycle metabolites by small molecule inhibitors ameliorate LPS induced immune tolerance in Macrophages through epigenetic mechanisms
• Katherine E. Lothstein, Rutgers Univ. New Jersey Med. Sch., Helminth TGF-β mimic, TGM, increases leukocyte migration and activation while also enhancing cutaneous wound healing and tissue regeneration

Chairs

• Ann Griffith, Univ. of Texas Hlth. Sci. Ctr. San Antonio
• Neetu Gupta, Cleveland Clin.

Speakers

• Sarah A. Wedemeyer, Univ. of Texas Hlth. Sci. Ctr. at San Antonio, Role of paracrine mTOR signaling in regulating thymus size and function
• Katherine Maude Ashby, Univ. of Minnesota, Thymic interferon impacts T cell selection
• Tom N. Taghon, Ghent Univ., Belgium, An unexpected role for IRF8 during human T cell development
• Breanna P. Caruso, Oregon Hlth. & Sci. Univ., A lineage specific role for PD-1 in agonist selection in the thymus
• Jonathan E. Boyson, Univ. of Vermont, Single-cell proteogenomics reveals that SLAM/SAP signaling regulates the development of innate-like γδ T cell subsets with distinct TCR repertoires
• Varun Aysola, Cleveland Clin., Ezrin promotes antigen receptor diversity during B cell development by supporting immunoglobulin heavy chain variable gene recombination
• Michael Jonathan Lehrke, Mayo Clin., ABCB7 is required for B cell development, proliferation, and class switch recombination

Chairs

• Maria Bettini, Univ. of Utah Sch. of Med.
• Kristin Hogquist, Univ. of Minnesota

Speakers

• Mekha A. Thomas, Johns Hopkins Univ. Sch. of Med., The monocyte cell surface as a novel site of autoantigen generation in Rheumatoid Arthritis
• Mianmian Yin, Univ. of California, San Francisco, Autoantigen specific T-cell receptor induces organ-specific autoimmunity by escaping T cell negative selection
• Alexander J. Dwyer, Univ. of Minnesota, CD4⁺ T cells targeting a hybrid insulin: chromogranin A self-antigen are necessary and sufficient for autoimmune diabetes initiation
• Yi Jing, Baylor Col. of Med., Insulin specific TCR repertoire analysis reveals functional diversity of Treg TCRs
• Paul Zdinak, Univ. of Pittsburgh Sch. of Med., Profiling transcriptomes, TCR repertoires, and antigenic specificities of islet-infiltrating T cells in non-obese diabetic mice
• Jun Hyung Sin, Univ. of California, San Francisco, Control of medullary thymic epithelial cell development and central tolerance by a zinc finger transcription factor
• Ryan J. Martinez, Univ. of Minnesota, Type III interferon enhances thymic B cell licensing
• Gregory J. Tsay, China Med. Univ., A specific 25-mer peptide from the cysteine protease of P. gingivalis is the epitope of humoral immune response in rheumatoid arthritis

Chairs

• Emily Hemann, The Ohio State Univ., Col. of Med.
• Paul Thomas, Saint Jude Children’s Res. Hosp.

Speakers

• Abigail Solstad, Ohio State Univ., Endogenous interferon-lambda signaling restricts virus replication and disease severity in a murine model of SARS-CoV-2 infection
• Jodi F. Hedges, Montana State Univ., ADAM-17 protease promotes inflammation and mortality while decreasing viral burden in a COVID-19 mouse model
• Xiao He, Univ. of Utah, A longitudinal study of humoral immune responses to SARS-CoV-2 spike proteins in gamma-interferon-inducible lysosomal thiol reductase deficient mice
• Hejun Liu, Scripps Res. Inst., The human IGHD3-22 encoded motif contributes to broad reactivity of anti-SARS-CoV-2 antibodies
• Jennifer R. Habel, Univ. of Melbourne, at Peter Doherty Inst. for Infection and Immunity, Integrated immune networks in SARS-CoV-2 infected pregnant women reveal differential NK cell and unconventional T cell activation
• Krista L. Newell, SUNY Upstate Med. Univ., Spike BATTLE: Simultaneous evaluation of antigen-specific B and T lymphocytes following natural SARS-CoV-2 infection and subsequent mRNA vaccination
• Alba Grifoni, La Jolla Inst. for Immunology, SARS-CoV-2 vaccination induces T cell memory responses able to cross-recognize ongoing SARS-CoV-2 variants including omicron
• Anastasia Minervina, St. Jude Children’s Res. Hosp., Epitope-specific T cell response to SARS-CoV-2 infection and vaccination

Chairs

• De’Broski Herbert, Univ. of Pennsylvania Sch. of Vet. Med.
• Tracey Lamb, Univ. of Utah

Speakers

• Jenna Reed, Univ. of Utah Sch. of Med., Plasmodium infection elevates risk of severe secondary bacterial disease by altering the immunological landscape of the lung
• Oscar Rosas Mejia, Ohio State Univ. Col. of Med., Mice infected with Mycobacterium tuberculosis are resistant to secondary infection with SARS-CoV-2
• Nicolas Olive Jean Millet, Harbor-Univ. of California, Los Angeles Med. Cntr., IL-23 signaling limits ferroptosis-driven immunopathology during systemic fungal infection
• Trung Hoang Minh Pham, Stanford Univ. Sch. of Med., Single-cell profiling identifies ACE⁺ granuloma macrophages as a non-permissive niche for intracellular bacteria during persistent Salmonella infection
• Yazmin Berenice Martinez-Martinez, Univ. of Texas Med. Br. at Galveston, HIV compromises Th17 and Th22 immunity in a humanized mouse model of Tuberculosis and HIV co-infection
• E. Evonne Jean, Univ. of Pennsylvania Sch. of Vet. Med., Exploring cutaneous neuro-immune networks during helminth infection
• Nana K. Minkah, Seattle Childrens Res. Inst., Type I Interferon remodels intrahepatocytic signaling to promote T cell dysfunction during liver stage Plasmodium infection
• Romaniya Zayats, Univ. of Manitoba, Cellular dynamics of immune evasion during Leishmania major infection

Chairs

• Benjamin Hurrell, Univ. of Southern California
• Omid Akbari, Keck Sch. of Med., Univ. of Southern California

Speakers

• Karine Bouchard, Quebec Heart and Lung Inst., Université Laval, Macrophage inflammatory response increases in adult female exposed to neonate stress
• Hector M. Nieves-Rosado, Univ. of Pittsburgh Sch. of Med., Tim-3 deletion on Treg increases virus-specific T cell response and reduces viral burden in chronic LCMV infection
• Kunal Dhume, Univ. of Central Florida, Robust homotypic and heterosubytpic immunity against Influenza A Virus in mice lacking Th1/Tc1 transcriptional machinery
• Manuja Gayashan Bandara Gunasena, Ohio State Univ., Immune determinants of cardiometabolic risk in pre-existing type-2 diabetes (T2D) severe COVID-19 patients
• Monique M. Waldman, Univ. of Colorado Anschutz Med. Campus, Ena/VASP protein-mediated actin polymerization contributes to naive CD8⁺ T cell activation and expansion by promoting T cell-APC interactions in vivo
• Mahmoud Abdelbary, Oregon Hlth. and Sci. Univ., Core fucosylation of N-linked glycans: a novel player in memory CD8⁺ T cell differentiation following acute viral infection
• Thu A. Doan, Univ. of Colorado Anschutz Med. Campus, Archived antigen boosts CD8 T cell memory responses during an unrelated infection

Chairs

• Rebecca Martin, Virginia Commonwealth Univ.
• De’Broski Herbert, Univ. of Pennsylvania Sch. of Vet. Med.

Speakers

• Jorge F. Ortiz-Carpena, Perelman Sch. of Med., Univ. of Pennsylvania, Sensory neurons shape allergic Type 2 inflammation in the sinonasal tract
• Anukul T. Shenoy, Boston Univ., Mouse model of late-onset neutrophilic asthma reveals an epithelium-lymphocyte-neutrophil communication circuit underlying destructive airway neutrophilia
• Jihyun Yu, Korea Advanced Inst. of Sci. and Technol., GPR43 signaling in lung eosinophils suppresses neutrophilic airway inflammation in asthma
• Rama Krishna Gurram, NHLBI, NIH, TSLP and IL-33 distinctively modulate the allergic response by differentially modulating Th2 cells and ILC2sM
• Anuj Tharakan, Virginia Commonwealth Univ. Sch. of Med., Blockade of dendritic cell glutaminolysis induces allergic asthma desensitization via suppression of Tfh13 polarization
• Abigail Pajulas, Indiana Univ. Sch. of Med., T_H9-derived IL-9 promotes CCR2-dependent mast cell accumulation in the allergic lung
• Ceire Hay, Perelman Sch. of Med., Univ. of Pennsylvania, Interrogating mechanisms of CD8 T cell dysfunction in obese asthma
• Lars P. Lunding, Res. Ctr. Borstel, The NLRP3 Inflammasome Inhibitor OLT1177® Ameliorates Experimental Allergic Asthma in Mice

Chairs

• Amelia Pinto, Saint Louis Univ. Sch. of Med.
• Majid Kazemian, Purdue Univ.

Speakers

• Elizabeth Geerling, St. Louis Univ., Sch. of Med., Metabolic syndrome enhances viral disease severity and reduces vaccine efficacy in mice
• Jian Zheng, Univ. of Iowa, Eicosanoid signaling as a therapeutic target in middle-aged mice with severe COVID-19
• Stephen T. Yeung, Weill Cornell Grad. Sch. of Med. Sci., Galectin-9 protects humanized-ACE2 immunocompetent mice from SARS-CoV-2 Infection
• Bingyu Yan, Purdue Univ., SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation
• Ksenia Rybkina, Columbia Univ. Med. Ctr., Children with Multi-System Inflammatory Syndrome (MIS-C) develop functionally competent T cell memory against SARS-CoV-2 following recovery
• Zehra Rahman, Univ. at Buffalo Sch. of Med. and BioMed. Sci., Exploration of shared antibody motifs in Kawasaki Disease (KD) and COVID-19 related Multisystem Inflammatory Syndrome of Childhood (MIS-C)
• Brandi L. Clark, St. Jude Children’s Res. Hosp., Identifying distinct T cell subsets in the context of pediatric ARDS
• Yu Gao, Karolinska Inst., SARS-CoV-2 mRNA vaccination induces polyfunctional T cell responses in healthy and immunocompromised individuals

Chairs

• Katelyn T. Byrne, Oregon Hlth. and Sci. Univ.
• Ichiko Kinjyo, Univ. of New Mexico

Speakers

• Jihae Ahn, Feinberg Sch. of Med., Northwestern Univ., Enhancing the antitumor response of CD8⁺ T cells by 4-1BB (CD137) co-stimulation with distinct inactivation of the type 2 adenosine receptors
• Mark E. Issa, Univ. of Montreal, Glycogen synthase kinase (GSK-3) synergizes with PD-1/PDL1 blockade to generate super-armed CD8 killers against tumors
• Sora Suzuki, Roswell Park Comprehensive Cancer Ctr., Complement C3 deficiency enhances anti-CD47 efficacy in murine ovarian cancer model
• Jasmine E. Trigg, Sartorius, Evaluation of checkpoint inhibitor therapies using a mixed lymphocyte reaction (MLR) assay
• Nikolaos E. Patsoukis, Beth Israel Deaconess Med. Ctr., Harvard Med. School, Treatment with exogenously added catalase promotes differentiation and function of central memory CD8⁺ T cells
• Allison Christians, Univ. of Colorado Anschutz Med. Campus, DNA-PK inhibition plus immune adjuvants promotes CD8 TIL infiltration, neoantigen presentation, and diversifies the tumor-reactive TCRβ repertoire in B16 melanoma
• Ichiko Kinjyo, Univ. of New Mexico, PARP-inhibition with IFNg in the ovarian tumor microenvironment induces immunogenic cancer cell death for sustained anti-tumor immunity