Autoantigen Identification, Autoantigen Specificity, and Central Tolerance

 Saturday, May 7, 2022     3:45 PM – 5:45 PM ET     Room B110–112

Autoantigen Identification, Autoantigen Specificity, and Central Tolerance

Chairs

• Maria Bettini, Univ. of Utah Sch. of Med.
• Kristin Hogquist, Univ. of Minnesota

Speakers

• Mekha A. Thomas, Johns Hopkins Univ. Sch. of Med., The monocyte cell surface as a novel site of autoantigen generation in Rheumatoid Arthritis
• Mianmian Yin, Univ. of California, San Francisco, Autoantigen specific T-cell receptor induces organ-specific autoimmunity by escaping T cell negative selection
• Alexander J. Dwyer, Univ. of Minnesota, CD4⁺ T cells targeting a hybrid insulin: chromogranin A self-antigen are necessary and sufficient for autoimmune diabetes initiation
• Yi Jing, Baylor Col. of Med., Insulin specific TCR repertoire analysis reveals functional diversity of Treg TCRs
• Paul Zdinak, Univ. of Pittsburgh Sch. of Med., Profiling transcriptomes, TCR repertoires, and antigenic specificities of islet-infiltrating T cells in non-obese diabetic mice
• Jun Hyung Sin, Univ. of California, San Francisco, Control of medullary thymic epithelial cell development and central tolerance by a zinc finger transcription factor
• Ryan J. Martinez, Univ. of Minnesota, Type III interferon enhances thymic B cell licensing
• Gregory J. Tsay, China Med. Univ., A specific 25-mer peptide from the cysteine protease of P. gingivalis is the epitope of humoral immune response in rheumatoid arthritis