IMMUNOLOGY2022™

May 6–10, 2022 | Portland, Oregon

Blocks Tuesday, May 10, 2022

Block Symposia

Full Listing
Fri. May 6
Sat. May 7
Sun. May 8
Mon. May 9
Tue. May 10

Tuesday, May 10, 2022

 Tuesday, May 10, 2022     8:00 AM – 10:00 AM     Room A107–109

Antigen Processing and Presentation II

Chairs

  • Lisa Denzin, Rutgers Univ. New Jersey Med. Sch.
  • Paul Roche, NCI,NIH

Speakers

  • Ashley M. Curran, Johns Hopkins Univ. Sch. of Med., Citrullination modulates MHC class II antigen processing and presentation by revealing cryptic epitopes
  • Camille Lake NIAID, NIH, Sequence similarity between SARS-CoV-2 Nucleocapsid and CNS proteins provides mechanistic insight into viral neuropathogenesis following infection
  • Jiangyuan Li, NIA, NIH, Repertoire size and predictability of influenza A virus matrix protein (M158-66)-specific CD8+ TCR
  • Swati Jaiswal, Univ. of Massachusetts Chan Med. Sch., Reverse Immunology: An approach to identify Mtb antigens recognized by T cells
  • Cori E. Fain, Mayo Clin., H-2Kb and H-2Db class I molecules on cerebral endothelium differentially modulate CD8 T cells dynamics and pathological outcomes in experimental cerebral malaria
  • Daniel Kyle Taylor, NIAID, NIH, Dynamic features of tapasin as revealed by structures of two tapasin/Fab complexes
  • Kahoko Hashimoto, Chiba Inst. of Technol., Autophagy in antigen presenting cells enhances the adjuvant effect by promoting antigen processing.
  • Shaodong Dai, Univ. of Colorado Anschutz Med. Campus, T cell recognition of disulfide modified antigens
 Tuesday, May 10, 2022     8:00 AM – 10:00 AM     Room B117–119

B Cell Differentiation, Regulation, and Function

Chairs

  • Thomas Forsthuber, Univ. of Texas San Antonio
  • Ginny L. Bumgardner, The Ohio State Univ. Med. Ctr.

Speakers

  • Juan Marcos Oviedo, Univ. of Utah, IL-4 Signaling Regulates the Fate of B Cell Differentiation and limits BCR repertoire
  • Jason M. Zimmerer, Wexner Med. Ctr., Ohio State Univ., Optimal development and effector function of antibody-suppressor CXCR5+CD8+ T cells requires host IFN-γ and CD4+ T cells
  • Sarah E. Webster, Western Michigan Univ. Homer Stryker MD Sch. of Med., Let's talk about sex, baby: sex influences age-related changes in natural antibodies and natural antibody producing B-1a cells
  • Austin Joseph Negron, Univ. of Texas San Antonio, The role of ERK2 in regulating germinal center B cell fate decisions
  • Amit K. Singh, NIA, NIH, Unique and shared molecular features of human B and T lymphocyte memory differentiation
  • James Knox, Perelman Sch. of Med., Univ. of Pennsylvania, Splenic T-bet+ B cells exhibit stem-like features and constitutively generate antibody-secreting cells
 Tuesday, May 10, 2022     8:00 AM – 10:00 AM     Room C123–124

Cytokine and Chemokine Control of Cellular Immunity

Chairs

  • Thomas Malek, Miller Sch. of Med., Univ. of Miami
  • Robert Welner, Univ. of Alabama at Birmingham

Speakers

  • Sergio Pontejo, NIAID, NIH, Chemokines and anionic phospholipids: new binding partners for microbial killing and apoptotic cell clearance
  • Haressh Sajiir, Mater Res. Inst., Univ. of Queensland, Pancreatic interleukin-22 receptor signaling is critical in maintaining beta-cell insulin production and is hepatoprotective
  • Victoria Matkins, Univ. of Alabama at Birmingham, Perturbations of Marrow Stromal Cell function during Acute Inflammation
  • Elizabeth M. Hill, Univ. of Maryland Sch. of Med., Collaboration of therapeutic, systemic IL12p40 with locally released IL12p35 focuses immunity to the tumor microenvironment
  • Marine Rousseau, Université de Montréal, Characterization of a new cytokine complex from the IL-6/IL-12 family
  • Rebecca Martin, Virginia Commonwealth Univ. Sch. of Med., Loss of ADAM17 from macrophages induces ST2+ T regulatory cells that limit obesity-induced metabolic inflammation in mice through changes in both membrane and soluble TNF
  • Acaci Crouch, Univ. of Miami Leonard M. Miller Sch. of Med., Interleukin-2 signaling engages de novo cholesterol biosynthesis in regulatory T cells
 Tuesday, May 10, 2022     8:00 AM – 10:00 AM     Room B110–112

Immunoregulation—Innate Immune Responses

Chairs

  • Meera Nair, Univ. of California, Riverside
  • Emily Howard, Univ. of Southern California

Speakers

  • Mandy I. Cheng, Univ. of California, Los Angeles, UTX is an epigenetic regulator of natural killer cell development and anti-viral effector function.
  • Ajay Kumar, Univ. of Michigan, Glutamine addiction in NKT cells is regulated by AMPK-mTORC1 axis
  • Zarina Brune, Feinstein Inst. for Med. Res., Northwell Hlth., IRF5 regulation of CD4+ T cell metabolism controls CD40L expression
  • Erin E. West, NHLBI, NIH, Setting the pace: CD4 T cell-intrinsic Arginase 1 orchestrates Th1 induction and contraction
  • Jing Li, Stanford Univ. Sch. of Med., Human KIR+CD8+ T cells target pathogenic T cells in Celiac disease and are active in autoimmune diseases and COVID-19
  • Peyman Ghorbani, Univ. of Ottawa, Choline metabolism underpins macrophage IL-4 polarization in vitro and in vivo
  • Mandy M. Chan, Washington Univ. in St Louis Sch. of Med., Enhancing lysosomal lipid metabolism prevents the loss of Kupffer cells in non-alcoholic steatohepatitis and attenuates liver pathology
 Tuesday, May 10, 2022     8:00 AM – 10:00 AM     Room B113–116

Non-Immune Therapies in Cancer

Chair

  • Michael Gough, Earle A Chiles, Providence Cancer Inst.

Speakers

  • Guilan Shi, Univ. of South Florida, Gene therapy increases MHC class-I and T cell Infiltration to promote anti-tumor immune response in 4T1 breast cancer model
  • Michael J. Gough, Providence Portland Med. Ctr., Fluorescence tagging to monitor CD8 T cell recirculation from the tumor to the tumor-draining lymph node: the impact of focal radiation therapy on recirculation
  • Hua Laura Liang, Univ. of Chicago, Induction of inflammatory macrophages in solid tumors by all-trans retinoic acid augments radiation efficacy
  • Michael Walsh, Harvard Med. School, IFNγ from IL-12 virotherapy stably controls tumors independent of T cell cytotoxicity and IFNγ sensing by tumor cells
  • Hongji Zhang, Wexner Med. Ctr., Ohio State Univ., Preoperative exercise therapy attenuates liver metastases following surgical stress by inducing Kupffer cells-mediated anti-tumor immunity
  • Khan Mohammad Imran, Translational Biology, Med. and Health, Virginia Tech, IFNγ mediated PD-L1 expression mitigate the immunomodulatory effect of irreversible electroporation on pancreatic cancer
 Tuesday, May 10, 2022     10:15 AM – 12:15 PM     Room C123–124

Adaptive Immunity in Inflammation

Chairs

  • Anne Satterthwaite, UT Southwestern Med. Center
  • Joshua Gray, Columbia Univ. Med. Ctr.

Speakers

  • Carlo Vanz, Univ. of Texas Hlth. at San Antonio, Dysfunction in B cell tolerance and activation in obesity
  • Julio Molineros, Janssen Res. and Devel., Leveraging genetic correlation across immune-mediated disease to gain insights into underpowered studies of rare conditions
  • Ana C. Costa da Silva, NIDCR, NIH, Pathogenic tissue-resident memory T cells in exocrine gland chronic graft-versus-host disease
  • Laure Campillo-Gimenez, Univ. of California, San Diego, Evidence for metabolic disturbances in the pathogenesis of immune-mediated disease in SAMP1/YitFcs Mice
  • Michael A. Silverman, Perelman Sch. of Med., Univ. of Pennsylvania, IgA deficiency destabilizes immunological homeostasis towards intestinal microbiota and increases the risk of systemic immune dysregulation
  • Swarna Beesetti, St. Jude Childrens Res. Hosp., Targeting the NLRP3 inflammasome in Rare hereditary blood disorder Fanconi Anemia
  • Yingcong Li, Univ. of California, San Diego, From genetic variants to diseases: the role of LACC1 in T cells
 Tuesday, May 10, 2022     10:15 AM – 12:15 PM     Room A107–109

Cells of the Innate Immune System

Chairs

  • Maninjay Atianand, Univ. of Pittsburgh
  • Dimitry Krementsov, Univ. of Vermont

Speakers

  • Sarah J. Sun, Univ. of Chicago, BCG vaccination impacts the epigenetic landscape of progenitor cells in human bone marrow
  • Dimitry N. Krementsov, Univ. of Vermont, LncRNA U90926 is induced in activated macrophages, encodes a novel secreted protein, and is protective in endotoxic shock
  • Kevin E. Vergara, Univ. of Pittsburgh Sch. of Med., The long noncoding RNA LUCAT1 promotes immune gene expression in human macrophages
  • Oscar A. Aguilar, Univ. of California, San Francisco, CD3ζ adaptor structure determines functional differences between human and mouse CD16 Fc-gamma receptor signaling in natural killer cells
  • Fernando Souza-Fonseca-Guimaraes, Univ. of Queensland Diamantina Inst., TGF-β and CIS inhibition synergistically enhance natural killer cell-based immunity
  • Zhenyu Zhong, Univ. of Texas Southwestern Med. Ctr., dNTP catabolism is a macrophage-intrinsic gatekeeper preventing NLRP3 inflammasome hyperactivation
  • Heather L. Caslin, Vanderbilt Univ., Do adipose macrophages remember obesity? Innate immune memory in weight cycling
 Tuesday, May 10, 2022     10:15 AM – 12:15 PM     Room B117–119

Immunity to Microbial, Parasitic, and Fungal Infections I

Chairs

  • Olandrewaju Morenikeji, Univ. of Pittsburgh at Bradford
  • Denise Monack, Stanford Univ. Sch. of Med.

Speakers

  • Yogesh Scindia, Univ. of Florida, Hepcidin deficiency increases susceptibility to disseminating candidiasis and renal failure
  • Claire Depew, Univ. of California, Davis, Sterile liver inflammation and T cell-intrinsic T-bet expression drive the formation of Tissue Resident Memory CD4 T cells that protect against systemic Salmonella infection
  • Erinn L. Donnelly, Univ. of Idaho, Basophil depletion alters host immunity, intestinal permeability and mammalian host-to-mosquito transmission in malaria
  • Javeed A. Shah, Univ. of Washington, The tuberculosis resistance protein TOLLIP prevents disease progression by regulating the integrated stress response in alveolar macrophages.
  • Andrew Thomas Martin, Univ. of Rochester Med. Ctr. Selective reprogramming of peritoneal macrophages by IFN-γ during acute Toxoplasma gondii infection
  • Teri Hreha, Washington Univ. in St Louis Sch. of Med., Androgen exposure alters the neutrophil response to pyelonephritis
  • Yanli Chen, Univ. of Maryland, Col. Park, TNF-α signaling is required for fungal clearance during brain infection with Cryptococcus neoformans via promoting the recruitment of CD4+ T cells and inflammatory monocytes
  • Brandon Keith Wilder, Oregon Hlth. and Sci. Univ., Malaria antigens are presented to CD8 T cells via the non-classical HLA-E
 Tuesday, May 10, 2022     10:15 AM – 12:15 PM     Room B110–112

Lymphocyte Homeostasis and Regulation

Chairs

  • Melanie Gubbels Bupp, Randolph-Macon Col.
  • Nu Zhang, Univ. of Texas Hlth. Sci. Ctr. at San Antonio

Speakers

  • Francesca Pala, NIAID, NIH, Profound abnormalities in thymic epithelial cells in Rag1 hypomorphic mice: implications for immune reconstitution after stem cell transplantation
  • Jason White, Osaka Univ., WPI Immunology Frontier Res. Ctr., Japan, T cell fate and central tolerance: using iTregs to elucidate the persistence of thymic development on a T cell's behavior
  • Byron B. Au-Yeung, Emory Univ. Sch. of Med., Strong tonic TCR signaling is associated with negative regulation of naive CD4+ T cells
  • Orchi Anannya, Cornell Univ., ITK tunes the Th17/Treg switch response by controlling calcium dependent signaling
  • Takesha R. Foster, Randolph-Macon Col., The Effect of malnutrition on T-cell circadian rhythms
  • Noor Bala, Col. of Vet. Med., Cornell Univ., Spatially restricted T-cell activation in inflamed tissues
  • Saranya Srinivasan, Univ. of Texas Hlth. Sci. Ctr. San Antonio, Age-dependent changes in the regulatory program of CD8+ Regulatory T cells (CD8+ Tregs)
 Tuesday, May 10, 2022     10:15 AM – 12:15 PM     Room A105–106

Molecular Mechanisms of T Cell Signaling

Chairs

  • Fabienne Gally, Natl. Jewish Hlth., Colorado
  • Kaushik Choudhuri, Univ. of Michigan Med. Sch.

Speakers

  • Fenglei Li, Univ. of Michigan Med. Sch., TCR-enriched microvesicles provide antigen-specific help for class-switched antibody production
  • Melissa Erin Cook, Washington Univ. in St. Louis, Sch. of Med., The ZFP36 family of RNA-binding proteins regulate homeostatic and autoreactive T cell responses
  • Jasmine Tuazon, Ohio State Univ. Col. of Med., The Ikaros zinc finger transcription factor Eos as a candidate regulator of TH2 differentiation and function
  • Nicole M. Carter, Johns Hopkins Univ. Sch. of Med., QRICH1 is a CARD11 interactor that negatively regulates T cell activation
  • Jacob W. Thompson, Univ. of Utah, Cell-specific roles for miR-155 during neuroinflammation
  • Wen Lu, Univ. of California, San Francisco, The phosphatidylinositol-transfer protein Nir3 modulates T cell development and function
  • Shuvam Mohan Chaudhuri, Feinberg Sch. of Med., Northwestern Univ., Mediator complex maintains peripheral T cell tolerance through enforcement of the quiescence module
  • Katja Aviszus, Natl. Jewish Hlth., Colorado, Absence of the fatty acid binding protein5 (FABP5) inhibits the establishment of resident memory T cells after a secondary Listeria monocytogenes infection
 Tuesday, May 10, 2022     10:15 AM – 12:15 PM     Room B113–116

Tumor Microenvironment (TME) II

Chairs

  • Ronald Buckanovich, Univ. of Pittsburgh
  • Fabiola Osorio, Univ. of Chile

Speakers

  • Holly Morrison, Col. of Vet. Med., Virginia Tech, Diminished noncanonical NF-κB signaling induces colitis-associated colorectal cancer susceptibility upon de-differentiation of epithelial cells
  • Sandra Cascio, Univ. of Pittsburgh Sch. of Med., Egfl6 promotes ovarian cancer progression by inducing the immunosuppressive functions of tumor-infiltrating myeloid cells.
  • Asima Abidi Radboudumc, Dendritic cells to prevent cancer: Immune responses against neoantigens after dendritic cell vaccination of Lynch Syndrome patients
  • Manisha Taya, Univ. of Texas Southwestern Med. Ctr., Ovarian cancer cell glucocorticoid receptor activity modulates cytokine secretion promoting infiltration of immunosuppressive cells into the tumor microenvironment
  • Megan Snyder, Boston Univ. Sch. of Med., Malignant cell expression of the aryl hydrocarbon receptor induces PD-L1 and immunosuppression in models of oral and lung cancer
  • Ellis, J. Tibbs, Univ. of Maryland Sch. of Med., Pro-tumoral role of Granzyme B to aid in invasion and metastasis.
  • Erin Gibbons, Univ. of Rochester Med. Ctr., Glycoprotein-NMB (GPNMB) is Pro-Tumorigenic in Lymphangioleiomyomatosis (LAM)
  • David Shihong Gao, Univ. of Pittsburgh Sch. of Med., Loss of p53 sensitizes tumor cells to immune checkpoint blockade therapy via upregulation of IL-33