Sunday, May 8, 2022
Sunday, May 8, 2022 8:00 AM – 10:00 AM Oregon Ballroom 202
B Cell and T Cell Helper Responses during Viral Infections
- Akiko Iwasaki, Yale Sch. of Med.
- Henrique Borges da Silva, Mayo Clin.
- Henrique Borges da Silva, Mayo Clin., Establishment of influenza-specific lung tissue-resident helper memory CD4+ T cells relies on expression the eATP sensor P2RX7
- E. Taylor Stone, St. Louis Univ, Sch. of Med., Requirement for robust T and B cell responses for immune protection against Powassan virus (POWV) in virus-like particle (VLP) vaccination
- Christopher Ned Jondle, Med. Col. of Wisconsin, T cell-intrinsic IL-17RA signaling in the spleen supports the establishment of chronic gammaherpesvirus infection
- Yexin Yang, Yale Sch. of Med., Glycan-specific B-1 cells mediate blockade of endogenous retroviruses emergence through recognition of conserved glycan epitopes
- Antonio Cembellin Prieto, Univ. of California, Davis, B cell-derived acetylcholine controls local inflammation and replication of influenza virus during respiratory tract infections
- Jalene V. Velazquez, Washington State Univ., Distinct antibody profiles against Ebola virus track with the development of Post-Ebola Syndrome.
- Ariana Denise Campbell, Johns Hopkins Bloomberg Sch. of Public Hlth., Influenza A virus-specific maternal antibodies impair vaccine-induced antibody responses and protection in male to a greater extent than female offspring
- Jenna Guthmiller, Univ. of Chicago, B cell convergence to distinct broadly reactive epitopes revealed by chimeric hemagglutinin vaccination
Sunday, May 8, 2022 8:00 AM – 10:00 AM Room B113–116
Big Data: The Key to Unlocking Immune Mediated Mechanisms of Tumor Progression and Therapy Response
- Mary Philip, Vanderbilt Univ. Med. Ctr.
- Sepideh Dolatshahi, Univ. of Virginia
- Joshua Brand, Univ. of Wisconsin-Madison, Single-cell myeloid diversity in human fallopian tube and its implications for early high grade serous ovarian cancer
- Nicola S. Meagher, Univ. of New South Wales, Multi-modal immune profiling of mucinous ovarian carcinoma: analysis from the Ovarian Tumor Tissue Analysis/Multidisciplinary Ovarian Cancer Outcomes Group consortia
- Mieszko Lachota, Med. Univ. of Warsaw, Analysis of chemokine network in primary human glioblastoma
- Cristina F. Contreras, NCI, NIH, Transcriptomic and epigenetic profiling of tumor-associated monocyte function
- Huy Dinh, Univ. of Wisconsin-Madison, Defining myeloid plasticity and heterogeneity in immunotherapy response
- Vivien Ileana Maltez, NIAID, NIH, Multiplex microscopy reveals unique spatiotemporal effects of cancer immunotherapies
- William L. Redmond, Earle A. Chiles Res. Inst., Multimodal single-cell analysis of human TILs across multiple tumor types reveals heterogeneity and potential opportunities for personalized immunotherapy
- Abigail L. Sedlacek, Univ. of Pittsburgh, Identification of immunogenic peptide neoantigens expressed in sarcomas and their therapeutic potential
Sunday, May 8, 2022 8:00 AM – 10:00 AM Oregon Ballroom 201
Infection and Disease
- Marta Catalfamo, Georgetown Univ. Sch. of Med.
- Bethany Mundy-Bosse, The Ohio State Univ. Col. of Med.
- Tanya Novak, Boston Children's Hosp. and Harvard Med. Sch., Genes associated with multiple organ dysfunction syndrome during severe pediatric influenza
- Julie G. Burel, La Jolla Inst. for Immunology, Profiling the myeloid compartment of PBMC in active tuberculosis reveals substantial changes in CD14+ cells and upregulation of CD16 in pro-inflammatory dendritic cells
- Jeffrey Alan Tomalka, Emory Univ. Sch. of Med., Inflammasomes and IL-1β: an innate immune axis in CD4+ T cells driving HIV infection and disease progression
- Hadas Tamar Pahima, Hebrew Univ. of Jerusalem, COVID-19 patients are characterized by increased levels of immune cell membrane-bound and soluble CD48
- Sarah C. Glover, Univ. of Mississippi Med. Ctr., Circulating extracellular vesicles from patients with severe COVID-19 upregulate Cathepsin B and activate STAT3 in normal human mesangial cells
- Josh S. Mytych, Oklahoma Med. Res. Fndn., Bacillus anthracis peptidoglycan alters human M2-like macrophage phenotype and efferocytic function in the presence of human serum
- Ismaila L. Manneh, London Sch. of Hygiene and Tropical Med., Targeted transcriptomic signature for monitoring anti-tuberculosis treatment response
- Yashoda Madaiah Hosakote, Univ. of Texas Med. Br. at Galveston, SARS-CoV-2 induced oxidative stress promotes HMGB1 secretion to induce inflammation
Sunday, May 8, 2022 8:00 AM – 10:00 AM Room B117–119
Molecular Mechanisms of Inflammation
- Kristin Patrick, Texas A&M Univ., Col. of Med.
- Brooke Napier, Portland State Univ.
- Haley M. Scott, Texas A&M Hlth. Sci. Ctr., Serine Arginine Splicing Factor 7 (SRSF7) is a critical regulator of innate immune activation in macrophages
- Stephanie R. Shames, Kansas State Univ., Effector-mediated subversion of proteasome activator (PA)28αβ enhances lysosomal pathogen targeting within cytokine-activated macrophages
- James Robert Fisher, Univ. of Texas Med. Br. at Galveston, Mincle and TNF signaling crosstalk enhances type 1 and innate immune responses to Orientia tsutsugamushi
- Antonio J. Pagán, Univ. of Cambridge, mTOR-associated mitochondrial energy metabolism limits mycobacterium ESX-1-induced cytotoxicity
- Amy Lorraine Seufert, Portland State Univ., Palmitic acid reprograms inflammatory responses to microbial ligands in macrophages, and mediates innate immune memory in vivo
- Haleigh Gilliland, Michigan State Univ., Defining complex mechanistic interactions and responses by macrophages during Mycobacterium abscessus infection
- Cheyenne Palm, Towson Univ., NADase activity found in bacterial TIR proteins may aid in innate immune evasion
- Michal Caspi Tal, Stanford Univ. Sch. of Med., P66 is a bacterial "don't eat me signal" that mimics mammalian CD47 and facilitates immune evasion by Borrelia burgdorferi
Sunday, May 8, 2022 8:00 AM – 8:00 AM Room A105–106
Mucosal Innate Immune Cells
- Andea Reboldi, Univ. of Massachusetts Med. Sch.
- Paige Porrett, Univ. of Alabama at Birmingham Sch. of Med.
- Wan-Jung Wu, Mem. Sloan Kettering Cancer Ctr., Select mucosa-associated intestinal commensal bacteria promote gut barrier repair by inducing IL-1b production
- Michela Frascoli, Univ. of Massachusetts Med. Sch., Crosstalk between skin homing innate T cells and epithelial cells via cholesterol byproduct messengers is required for tissue immunity
- Jia Nie, NCI, NIH, The transcription factor LRF promotes Integrin β7 expression by and gut homing of CD8αα intraepithelial lymphocyte precursors
- Xuqiu Lei, Univ. of Massachusetts Chan Med. Sch., Epithelial HNF4A shapes the intraepithelial lymphocyte compartment via direct regulation of immune signaling molecules
- Angeline Chen, La Jolla Inst. for Immunology, Small intestine epithelial CD4 cytotoxic T lymphocytes provide innate-like protection against enteric pathogens without risk of immunopathology
- Paige Porrett, Univ. of Alabama at Birmingham Sch. of Med., Aberrant survival of uterine natural killer subsets in uterus transplant recipients
- Thanh Thanh Trinh Dinh, The Ohio State Univ. Col. of Med., ILC3 expansion in acute myeloid leukemia
Sunday, May 8, 2022 8:00 AM – 10:00 AM Room C123–124
T Cell Effector Generation and Function
- Takeshi Egawa, Washington Univ. Sch. of Med.
- Sarah Hamilton, Univ. of Minnesota
- Anna Halling Folkmar Andersen, Aarhus Univ., Single-cell TCR and mRNA sequencing of antigen-specific T cells reveal spatial trajectories from single time points with HLA and VDJ bias
- Ao Guo, St. Jude Children's Res. Hosp., The SWI/SNF canonical BAF complex and c-Myc cooperate to promote early fate decisions in CD8+ T cells
- Jessica A. Gaevert, St. Jude Children's Res. Hosp., Characterization of the cross-reactive T cell repertoire in the context of heterosubtypic influenza A virus infection
- Erin D. Lucas, Univ. of Minnesota, Expansion and maintenance of long lived effector CD8 T cells is modulated by inflammation
- Yu Xia, Washington Univ. in St Louis Sch. of Med., BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4 T cell responses to persistent antigen
- Mirela Kuka, Università Vita Salute San Raffaele, A fluorescent reporter model to study the role of TDC during infection and cancer
Sunday, May 8, 2022 10:15 AM – 12:15 PM Oregon Ballroom 201
Primary Immune Deficiency and Immune Dysregulation
- Emily M. Mace, Columbia Univ.
- Elissa Deenick, Garvan Inst. of Med. Res.
- Ruth J. Napier, Oregon Hlth. and Sci. Univ., T cell intrinsic role for NOD2 in Blau Syndrome
- Marita Bosticardo, NIAID, NIH, Characterization of thymic epithelial cell and thymocyte function and development in patients with thymic defects using scRNAseq profiling
- Zinan Zhang, Harvard Med. Sch., Bi-allelic TTC21A mutations in common variable immunodeficiency patients
- Sukalp Muzumdar, Cold Spring Harbor Lab., A granular view of X-linked chronic granulomatous disease exploiting single-cell transcriptomics
- Julia Bier, Garvan Inst. of Med. Res., Australia, T cell extrinsic mechanics explaining the T cell hyperactivation seen in Activated PI3K δ Syndrome
- Nicolai S. van Oers, Univ. of Texas Southwestern Med. Ctr., 22q11.2 deletion syndrome causes a thymus hypoplasia corrected by mesenchymal cell replacement
- Olivia Bailey, Univ. of Colorado Anschutz Med. Campus, Dissecting the effect of a novel hypomorphic IL2RB mutation on immune dysregulation
- Jose S. Campos Duran, Perelman Sch. of Med., Univ. of Pennsylvania, Dysregulation of CD8+ T cell function in the setting of altered cytokine signaling due to inborn errors of immunity
Sunday, May 8, 2022 10:15 AM – 12:15 PM Oregon Ballroom 204
Technological Innovations in Immunology II
- Amanda M. Burkhardt, Univ. of Southern California
- Yuri Sykulev, Thomas Jefferson Univ.
- Joseph Cornelius Lownik, Cedars Sinai Med. Ctr., Expanding the use of clustering and dimensionality reduction in high parameter flow cytometry data through machine learning for novel samples
- Vaishnavi Kaipilyawar, Rutgers New Jersey Med. Sch., Derivation of a parsimonious Tuberculosis gene signature using the digital NanoString nCounter platform
- Lanaiah M. Ieremia, Texas Tech Univ. Hlth. Sci. Ctr. El Paso, Host-targeted self-attenuated influenza virus as a potential therapeutic influenza vaccine
- Shijie Cao, Univ. of Chicago, Lymph node-targeted long-acting butyrate micelles induce regulatory immune modulation
- Sophia Liu, MIT, Spatially mapping T cell receptors and transcriptomes
- Irene E. Whitney, Honeycomb Biotechnologies, HIVE Single-cell TCR sequencing: assay principle and applications
- Sheila Burns, Applied Cells, Inc., A multi-physics approach for high recovery and purity isolation of plasma cells in whole blood
Sunday, May 8, 2022 10:15 AM – 12:15 PM Oregon Ballroom 202
Tissue-Resident Memory T Cells (Trm) in Cancer
- Jose R. Conejo-Garcia, H. Lee Moffitt Cancer Ctr. and Res. Inst.
- Fathia Mami-Chouaib, INSERM U1186, France
- Hui Zhang, Washington State Univ., Tissue-resident memory CD4+ T cells play a dominant role in the initiation of antitumor immunity
- Michael J. Gough, Providence Portland Med. Ctr., Tumor resident memory CD8 T cell formation and concomitant tumor immunity is CD40L dependent and CD4 independent
- Nu Zhang, Univ. of Texas Hlth. Sci. Ctr. at San Antonio, TGF-β-dependent Lymphoid Tissue Residency of Stem-like T cells Limits the Response to Tumor Vaccine
- Carmen Mariam Anadon Galindo, H. Lee Moffitt Cancer Ctr. and Res. Inst., Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T-cells
- Noah Veis Gavil, Univ. of Minnesota, Chronic antigen in solid tumors drives a distinct program of T cell residence
- Fathia Mami-Chouaib, INSERM U1186, France, Resident memory T cells in antitumor immunity and cancer immunotherapy
Sunday, May 8, 2022 12:30 PM – 2:30 PM Room B113–116
The Impact of the Commensal Microbiome on Cancer Progression and Therapy Response
- Melanie R. Rutkowski, Univ. of Virginia
- Irving Allen, Col. of Vet. Med.. Virginia Tech
- Kaiting Yang, Univ. of Chicago, Suppression of local IFN-I by commensal microbiota-derived butyrate impairs antitumor effects of ionizing radiation
- Qingsheng Li, Univ. of Louisville, Dietary low-fiber promotes resistance to immune checkpoint inhibitor immunotherapy in the LSL-KrasG12D Lung Cancer Model
- Romina E. Araya, NCI, NIH, Neutrophil dynamics in the tumor microenvironment determines therapy efficacy and is regulated by microbiota
- Liangliang Wang, Univ. of Chicago, Lactobacillus rhamnosus GG re-shapes gut microbiota and triggers STING-type I IFN-dependent antitumor immunity
- Mitchell Thomas McGinty, Univ. of Virginia, Absence of Toll-like receptor 5 confers survival in mice bearing ovarian tumors treated with anti-PD-L1
- Qingsheng Li, Univ. of Louisville, Resistance to Anti-PD-1 Therapy is mediated via the Microbiota-Th17-Prostoglandin E2 Axis in the LSLKrasG12D Lung Cancer Model
- Khiem C. Lam, NCI, NIH, Tumor-intrinsic factors dictate beneficial effect of microbiota-based therapies
Sunday, May 8, 2022 12:30 PM – 2:30 PM Oregon Ballroom 203
Innate Immunity to Viral Infection
- Paul Thomas, St. Jude Children's Res. Hosp.
- Shitao Li, Tulane Univ. Sch. of Med.
- Yakun Wu, Tulane Univ. Sch. of Med., Nuclear soluble cGAS senses DNA virus infection
- Murugesan Rajaram, Ohio State Univ., Influenza A virus modulates ACE2 expression and SARS-CoV-2 infectivity in human cardiomyocytes
- Jenny Resiliac, Research Institute at Nationwide Children's Hospital, Lipopolysaccharide pre-treatment prevents viral induced death by priming macrophages for a robust anti-viral immune response
- Yi Yao, Henry Ford Hlth. Sys., Circulating monocytes co-expressing surface ACE2 and TMPRSS2 upon TLR4/7/8 activation are susceptible to SARS-CoV-2 infection
- Jennifer R. Connors, Drexel Univ. Col. of Med., The impact of lipid nanoparticles (LNP) on anti-viral pathways and immune function in aged individuals
- Marissa Lindman, Rutgers Univ., Astrocytic RIPK3 confers protection against deleterious neuroinflammation during Zika virus infection
- Anshu Agrawal, Univ. of California Irvine, Innate immune mechanisms underlying sex differences in COVID-19
Sunday, May 8, 2022 12:30 PM – 2:30 PM Room B110–112
Innate Signaling, Microbiome, and Metabolism in Autoimmunity
- Leah Kottyan, Cincinnati Children's Med. Ctr.
- Betsy Barnes, The Feinstein Inst. for Med. Res., Northwell Hlth.
- Bharati Matta, Feinstein Inst. for Med. Res., IRF5 risk variants contribute to pre-symptomatic SLE by enhancing the levels of circulating NET antigens
- Morgan Lee Terrell, Univ. of Florida, Treatment with TLR7/8 agonist compromises intestinal epithelium integrity in a lupus prone mouse model
- Kevin MingJie Gao, Univ. of Massachusetts Med. Sch., Radioresistant cells in STING gain-of-function mice initiate lymphocyte dependent lung inflammation and IFNγ dependent mortality
- David Nemazee, Scripps Res. Inst., Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors, including endolysosomal TLRs and a STING dependent sensing pathway
- Mitra Padideh Maz, Univ. of Michigan, Understanding innate immune cell-mediated inflammation in UV-induced skin injury in lupus-prone mice
- William J. Turbitt, Univ. of Alabama at Birmingham, Neutrophil-specific Socs3 deficiency induces brain-targeted experimental autoimmune encephalomyelitis with enhanced cerebellar neutrophil activation
- Shailesh K. Shahi, Univ. of Iowa, HLA Class II polymorphisms influence gut microbiota composition and modulate disease in transgenic mice model of multiple sclerosis
- Mary A. Markiewicz, Univ. of Kansas Med. Ctr., The role of NKG2D signaling in NOD diabetes is affected by the microbiota
Sunday, May 8, 2022 12:30 PM – 2:30 PM Room B117–119
Neuronal and Central Nervous System Immunity
- Aaron Johnson, Mayo Clin. Rochester
- Arya Biragyn, NIA, NIH, A surprising pathogenic role of B cells in mice with Alzheimer's disease
- Pooja Jain, Drexel Univ. Col. of Med., Nutraceutical Apigenin regulates DC function in a RelB-dependent manner during neuroinflammation
- Zhangying Chen, Feinberg Sch. of Med., Northwestern Univ., T-cell infiltrates and microglia adopt long-term gene signature changes leading to age-specific responses to traumatic brain injury in mice
- Ling Cao, Univ. of New England, Responses of injured nerve in CD137L knockout mice following sciatic nerve crush-induced neuropathic pain
- Murugaiyan Gopal, Brigham and Women's Hosp. and Harvard Med. Sch., MicroRNA control of inflammatory and regulatory T cells in CNS autoimmunity
- Ling Cao, Univ. of New England, Electromyographic characterization and bioinformatic pathway analysis of spinal cord inflammation in a Tat induced HIV-associated sensory neuropathy model
- Yan Wang, Thomas Jefferson Univ., Single-cell RNA sequence (scRNAseq) analysis of T regulatory cells in relapsing remitting multiple sclerosis (RRMS)
Sunday, May 8, 2022 12:30 PM – 2:30 PM Oregon Ballroom 202
Vaccines and Immunity against Bacteria and Parasites
- JoAnne L. Flynn, Univ. of Pittsburgh Sch. of Med.
- David A. Rosen, Washington Univ. Sch. of Med.
- Yanli Li, Univ. of North Carolina at Chapel Hill, Identification of CPAF as the immunoprevalent antigen of Chlamydia trachomatis
- Jaikin Harrell, Tulane Univ. Sch. of Med., The use of outer membrane vesicles as novel, mucosal adjuvants against intracellular bactiera
- Matthew Bell, Drexel Univ. Col. of Med., The novel adjuvant, ADA-1, restores age-associated defects in the adaptive immune response to Clostridioides difficile infection and vaccination in an aging mouse model
- Valery Cristina Román-Cruz, Univ. of Montana, Adjuvanted multivalent vaccine targeting clinically relevant Pf bacteriophage creates cross-reactive antibodies
- Paeton L. Wantuch, Washington Univ. Sch. of Med., Differential Immune Response to Klebsiella pneumoniae O-antigen subtypes O2v1 and O2v2
- Andrew W. Simonson, Univ. of Pittsburgh Sch. of Med., The role of lymphocyte subsets in preventing tuberculosis following intravenous vaccination with BCG
- Eva Morgun, Feinberg Sch. of Med., Northwestern Univ., Mycolic acid nanoparticle vaccination leads to antigen persistence and unique differentiation of mycobacterial lipid antigen-specific T cells
- Caroline J. Duncombe, Univ. of Washington, Differential sex-specific immune responses following Prime-and-Trap vaccination alters protection against malaria in mice
Sunday, May 8, 2022 3:45 PM – 5:45 PM Room A105–106
CD4+ T Cells in Cancer
- Stephen Schoenberger, La Jolla Inst. for Immunology
- Steven Ziegler, Benaroya Res. Inst.
- Spencer E. Brightman, La Jolla Inst. for Immunology, TCR-engineered neoantigen-specific CD4+ T cells mediate immunotherapy of a class II-negative murine squamous cell carcinoma
- Katelyn T. Byrne, Perelman Sch. of Med., Univ. of Pennsylvania, CD4+ T cells mediate non-canonical rejection of major histocompatibility class-I deficient pancreatic tumors independently of CD8+ T cells
- Dan Chen, Salk Inst. for Biological Studies, Dissecting anti-tumor immunity in glioblastoma
- Ying Zheng, Johns Hopkins Univ. Sch. of Med., Target the activin receptor 1c on CD4+ T cells to achieve anti-tumor therapeutic effects
- Hsin Yu Liu, La Jolla Inst. for Immunology, Leveraging the Treg-intrinsic CTLA4-PKCη signaling pathway for cancer immunotherapy
- Kazushige Obata-Ninomiya, Benaroya Res. Inst., Virginia Mason, Thymic stromal lymphopoietin (TSLP) receptor signaling controls a tumorigenic Treg to promote colorectal cancer
- Kai Yang, Indiana Univ. Sch. of Med., The glutathione peroxidase Gpx4 prevents Treg lipid peroxidation and ferroptosis to facilitate tumor immunoevasion
Sunday, May 8, 2022 3:45 PM – 5:45 PM Oregon Ballroom 201
CD8+ T Cell Immunity to Viral Infections
- Benjamin Youngblood, Saint Jude Children's Res. Hosp.
- Erietta Stelekati, Miller Sch. of Med., Univ. of Miami
- Blair K. Hardman, Univ. of British Columbia, Differential localization and kinetics of antiviral CD8+ T cell responses to chronic and acute murine norovirus infections from initiation onwards
- Jia Zhu, Univ. of Washington, In situ characterization of lesion-forming human HSV-2 reactivation reveals distinct innate and adaptive immune compartmentalization
- Adolfo B. Frias, St. Jude Children's Res. Hosp., HIV-specific CD8+ T cells from elite controllers have an epigenetic imprint that preserves effector functions
- Blake Torrance, UConn Hlth., Role of p16 expressing cells in formation and function of T cell memory with age
- Xuebing Leng, Miller Sch. of Med., Univ. of Miami, MicroRNA-29a attenuates exhaustion and promotes memory-like CD8+ T cells
- Genevieve N. Mullins, Univ. of North Carolina at Chapel Hill, CD8+ T cell exhaustion is dynamically controlled by the chromatin regulator factor BRD4
- Roman Khadka, Mayo Clin., A novel approach to define contribution of microglia and brain endothelium in antigen specific CD8+ T cell-mediated blood brain barrier (BBB) disruption during virus infection
- Jennifer Berger, Univ. of Colorado Anschutz Med. Campus, A unique gammadelta T cell population in the brain during viral infection
Sunday, May 8, 2022 3:45 PM – 5:45 PM Oregon Ballroom 202
Therapies for Rheumatic Diseases and Beyond
- Randy S. Longman, Weill Cornell Med.
- Laurence M. Morel, Univ. of Florida Col. of Med.
- Rinkesh Kumar Gupta, La Jolla Inst. for Immunology, Therapeutic targeting of tumor necrosis factor like weak inducer of apoptosis (TWEAK) in psoriasis
- Yogesh Scindia, Univ. of Florida, Renal tubular cell ferroptosis: a new player in pathogenesis of lupus nephritis
- Ahmed Samir Elshikha, Univ. of Florida, The gut microbiota transfers the therapeutic effect of inhibiting glucose metabolism in lupus-prone mice
- Svetlana Ferreira Lima, Weill Cornell Med., Defining the role for the gut microbiome in the clinical efficacy of sulfasalazine therapy for IBD associated spondyloarthritis
- Longhuan Ma, Univ. of Florida, A combination of genetic factors and dietary tryptophan shapes gut microbial dysbiosis in a lupus-prone mouse model
- Laura Santambrogio, Weill Cornell Med., Characterization of a novel anti-inflammatory biogenic amine
- Hu Zeng, Mayo Clin. Rochester, The immune dysregulations in inflammatory arthritis immune related adverse events
- Justin Choe, Mayo Clin. Grad. Sch. of BioMed. Sci., ST8Sia6 expression in beta cells mitigates onset of autoimmune diabetes in the murine NOD model
Sunday, May 8, 2022 3:45 PM – 5:45 PM Oregon Ballroom 203
Transplant Immunology: Novel Mechanisms and Interventions
- Giorgio Raimondi, Johns Hopkins Univ. Sch. of Med.
- Maria-Luisa Alegre, Univ. of Chicago
- Gavin I. Ellis, Univ. of Pennsylvania, Alloantigen-specific Chimeric Antigen Receptor Regulatory T cell therapy in non-human primate islet transplantation
- Feiyan Mo, Baylor Col. of Med., Engineering T cells to prevent graft-versus-host disease and leukemia relapse following allogeneic stem cell transplantation
- Caroline Anna Markmann, Perelman Sch. of Med., Univ. of Pennsylvania, Leveraging CAR T cells to achieve desensitization and enable transplantation
- Jordan Warunek, Univ. of Pittsburgh Sch. of Med., Paired immunoglobulin-like receptors impact the differentiation of reparative macrophages following allogeneic challenge
- Fathima A. Mohamed, Univ. of Minnesota, Targeting temporal metabolic needs of T follicular helper cells to treat cGVHD utilizing a mitochondrial pyruvate carrier inhibitor
- Michael Nicosia, Cleveland Clin. Fndn., The role of LAG3 in antibody responses to kidney transplantation
- Peter Wang, Univ. of Chicago, Oral alloantigen exposure promotes donor-specific tolerance in a mouse model of minor mismatched skin transplantation
- Jared Pollard, Univ. of Chicago, Graft-matched pregnancy imparts profound epigenetic changes onto alloreactive memory t cells to enforce a phenotypic and transcriptional state of tolerance
Sunday, May 8, 2022 3:45 PM – 5:45 PM Room B113–116
Tumor Microenvironment (TME) I
- Dorina Avram, H. Lee Moffitt Cancer Ctr. and Res. Inst.
- Gunjan Mandal, H. Lee Moffitt Cancer Ctr. and Res. Inst., Spontaneous class-switched antibody responses at endometrial cancer tumor bed drives superior patients' outcome
- Zihan Guo, Oregon Hlth. and Sci. Univ., Class switching is required for antigen-dependent b cell anti-tumor activity
- Zhi-Zhang Yang, Mayo Clin., T-cell phenotype varies in distinct tumor microenvironments and CD57+ TFH cells are associated with disease progression and inferior survival in follicular lymphoma
- Juyeun Lee, Cleveland Clin. Fndn., Sex-specific T cell behavior drives differential immune responses in mouse glioblastoma models
- Stephanie Gomez, George Washington Univ., Inhibition of DNMTs and RNA editing increases immunogenic transposable element RNA to reduce tumor burden and prolong survival in a murine ovarian cancer model
- Tahereh Ziglari, Oregon Hlth. and Sci. Univ., Senescent cell-derived extracellular vesicles are critical elements in senescence surveillance by recruiting antigen-presenting cells
- Thejaswini Giridharan, Roswell Park Comprehensive Cancer Ctr., Role of the extracellular ATP/adenosine pathway in neutrophil-mediated T cell suppression in ovarian cancer microenvironment
Sunday, May 8, 2022 3:45 PM – 5:45 PM Oregon Ballroom 204
Vaccination and Immunotherapy against COVID-19
- Donna L. Farber, Columbia Univ. Med. Ctr.
- James J. Kobie, Univ. of Alabama at Birmingham
- Ebony Nicole Gary, Wistar Inst., Peripheral co-immunization with CCL27 drives robust mucosal responses to SARS-CoV-2 synDNA antigens and provides heterologous protection against Delta variant challenge
- Vanessa S. Moraes, Univ. of Georgia, Polyfunctionality of T cell immunity in pre-immune and naïve individuals after COVID-19 mRNA vaccination
- Elizabeth A. Thompson, Johns Hopkins Univ. Sch. of Med., Alternative lineage B cells utilizing fatty acid oxidation predict response to third dose COVID vaccination in solid organ transplant recipients
- James Kobie, Univ. of Alabama at Birmingham, Pan-coronavirus neutralizing S2 human monoclonal antibodies and utility of direct respiratory administration as combination therapy with S1 antibodies against SARS-CoV-2
- Timothy A. Bates, Oregon Hlth. and Sci. Univ., Hybrid immunity and vaccine breakthrough lead to robust humoral response and antibodies that effectively neutralize SARS-CoV-2 variants
- Eric S. Geanes, Children's Mercy Kansas City, Differences between autoantibodies induced by SARS-CoV-2 infection and Pfizer-BioNTech SARS-CoV-2 vaccination
- Julia Davis-Porada, Columbia Univ. Med. Ctr., Persistence of immune memory to SARS-CoV-2 vaccine in lymphoid tissue
- John D. Mountz, Univ. of Alabama at Birmingham, IL-4R blockade prevents a long term memory B cell response to COVID-19 vaccination