Block Symposia
Monday, May 9, 2022
Monday, May 9, 2022 8:00 AM – 10:00 AM Room C123–124
CD4+ T Cell Regulation and Responses: Molecular Mechanisms
Chairs
- Claire Chougnet, Cincinnati Children's Med. Ctr.
- Tammy Kielian, Univ. of Nebraska Med. Ctr.
Speakers
- Laura Melissa Atehortua, Cincinnati Children's Hosp. Med. Ctr., Apolipoprotein E enhance survival of effector memory regulatory T lymphocytes by regulating caspase-dependent apoptosis and lipid metabolism
- Gunjan Kak, Univ. of Nebraska Med. Ctr., Th1 and Th17 cells are critical for limiting the severity of Staphylococcus aureus craniotomy infection
- Ying Ding, Miller Sch. of Med., Univ. of Miami, Blimp1 regulates the growth and function of human regulatory T cells
- Cody Mowery, Gladstone Inst., CRISPR-based functional genomics to decode cis and trans regulation of the CD28, CTLA4, and ICOS costimulatory locus
- Duy Pham, Univ. of Alabama at Birmingham, Sch. of Med., Batf stabilizes the th17 cell developmental program through impairment of stat5-dependent recruitment of Ets1-Runx1 complexes
- Michelle Chu, Indiana Univ. Sch. of Med., TL1A promotes a multi-cytokine Th9 cell phenotype
- Wesley H. Godfrey, Johns Hopkins Univ. Sch. of Med., Inhibition of distinct glycolytic enzymes produces differential effects on CD4 T cell function
- Dean R. Tantin, Univ. of Utah Sch. of Med., Transcription coactivator OCA-B/Pou2af1 is necessary and sufficient to promote T cell-intrinsic CD4 memory
Monday, May 9, 2022 8:00 AM – 10:00 AM Oregon Ballroom 202
Mechanisms of Viral Sensing and Innate Immune Responses
Chairs
- Steven Varga, Department of Microbiology and Immunology
- Sachin Mulik, Univ. of Texas Hlth. Sci. Ctr. at Tyler
Speakers
- Kody Waldstein, Univ. of Iowa, Alveolar macrophages act as an early viral sponge inducing long-lived functional enhancement
- Lauren A. Chang, Icahn Sch. of Med. at Mount Sinai, Vaccination modulates pulmonary eosinophil subsets upon breakthrough influenza infection
- Nina R. Derby, Seattle Children's Res. Inst., Liver biopsies reveal temporal changes in pathology and macrophage function following SIV infection of rhesus macaques
- Chiefe Mo, California State Polytechnical Univ., Pomona, DEC-205-expressing dendritic cells inhibit T cell responses during West Nile Virus encephalitis in the central nervous system
- Marcus P. Wong, Univ. of California, Berkeley, Investigating the role of inflammasome activation by dengue virus non-structural protein 1 during dengue infection
- Daniel Miranda, Western Univ. of Hlth. Sci., A viral homologue of IPS-1 that reprograms innate immunity during viral replication
- Weshely Kujur, Univ. of Texas Hlth. Sci. Ctr. at Tyler, Heterogeneity in NK memory stem cells after Zika virus infection using single cell approaches
- Isaac J. Jensen, Columbia Univ. Med. Ctr., Novel mouse model of MCMV-induced adaptive NK cells
Monday, May 9, 2022 8:00 AM – 10:00 AM Room A105–106
Microbiota and Epithelial Interactions
Chairs
- Gretchen Diehl, Mem. Sloan Kettering Cancer Ctr.
- Bei Liu, The Ohio State Univ.
Speakers
- Soo M. Ngoi, Ohio State Univ., Migratory type 2 dendritic cells mediate mucosal Th17 response to gut commensal bacteria
- Daniel Fernando Zegarra Ruiz, Mem. Sloan Kettering Cancer Ctr., Microbiota regulation of intestinal inflammation influences colorectal cancer
- Emily M. Eshleman, Cincinnati Children's Hosp. Med. Ctr., Epithelial MHC class II directs microbiota-specific intestinal immune homeostasis
- Elisabeth G. Foerster, Univ. of Toronto, Canada, Intestinal epithelial autophagy protects from cytokine-driven mortality and IFNγ-dependent cell death in acute small intestinal injury
- Madeline J. Churchill, Oregon Hlth. and Sci. Univ., NAIP—NLRC4 inflammasome activation in tuft cells contributes to host defense against bacteria
- Vini John, Washington Univ. Sch. of Med. in St.Louis, Goblet cells regulate expansion of colonic iNKT cells in CD1d-dependent manner
- Simona Ceglia, Univ. of Massachusetts Med. School, Epithelial-derived oxysterol production tunes intestinal IgA secretion against commensals and enteric pathogen in tissue
- Sarah E. Webster, Western Michigan Univ. Homer Stryker MD Sch. of Med., Influence of age, sex, and location on the diversity of the murine gut microbiome and/or expression of pro-inflammatory cytokines
Monday, May 9, 2022 8:00 AM – 10:00 AM Room A107–109
Tissue Inflammation
Chairs
- Amanda Jamieson, Brown Univ.
- Anna Beaudin, Univ. of Utah Sch. of Med.
Speakers
- Bridget Ratitong, Univ. of California, Irvine, The role of IL-1a during early-stage Pseudomonas aeruginosa infection of the corneas
- Jingbo Pang, Univ. of Illinois at Chicago, Monocyte/macrophage heterogeneity during skin wound healing in mice
- Priyanka Talukdar, Univ. of Pittsburgh, Type III IFNs (IFNλs) expressed in tuberculosis (TB) granulomas enhance anti-mycobacterial activity of macrophages
- Meredith Crane, Brown Univ., Pulmonary infection following skin injury delays wound healing through suppression of IL-1 and chemokine production
- Vinod Nadella, NIAMS, NIH, The extracellular matrix maintained by hypodermal macrophages via IGF1 is a niche for Staphylococcus aureus infection
- Stephanie Seveau, Ohio State Univ. Col. of Med., Inflammatory responses to Listeria monocytogenes infection in the placenta
- Marcelina Pyclik, Oklahoma Med. Res. Fndn., STING activation under pre-existing inflammatory conditions causes severe skin disease
Monday, May 9, 2022 10:15 AM – 12:15 PM Room A105–106
Cytokine and Regulatory Cell Control of Autoimmunity
Chairs
- Ziaur Rahman, Pennsylvania State Univ. Col. of Med.
- Edwin Wan, West Virginia Univ.
Speakers
- Ivy L. Debreceni, Univ. of Iowa, IL-27 signaling contributes to pathogenic T cells in a mouse model of Sjögren's
- Gabriel Arellano,Northwestern Univ., Interferon-gamma controls pathogenic T-helper 17 and B cells in a new Aquaporin-4 induced experimental autoimmune encephalomyelitis
- Tse-Hua Tan, Natl. Hlth. Res. Inst., MAP4K3/GLK is a novel therapeutic target for IL-17A-mediated autoimmune diseases
- Kelly Lynn Monaghan, West Virginia Univ., Sch. of Med., Tetramerization of STAT5 promotes autoimmune-mediated neuroinflammation
- Mianmian Yin, Univ. of California, San Francisco, Development of uveitis in a mouse model of spontaneous autoimmunity correlates with frequency of autoantigen-specific regulatory T cells
- Seung-Chul Choi, Univ. of Florida, Homeodomain protein Pbx1 regulates regulatory T cell development, stability and suppressive function
- Ulus Atasoy, Michigan Med. at Univ. of Michigan, Treg-specific ablation of HuR results in systemic autoimmunity associated with decreased TLR4 activation and IL-1β production
- Sarah Pasquin, Université de Montréal, Canada, Investigating immune tolerance: characterization of immunoregulatory DN T cells
Monday, May 9, 2022 10:15 AM – 12:15 PM Oregon Ballroom 202
Food Allergy, Atopic Dermatitis, and Mast Cells, Oh My!
Chairs
- Mark Kaplan, Indiana Univ. Sch. of Med.
- Adrian Piliponsky, Seattle Children's Res. Inst.
Speakers
- Lauren A. Hesser, Univ. of Chicago, Developing a synbiotic biotherapy to prevent allergic responses to food
- Nada Salem Alakhras, Indiana Univ. Sch. of Med., Covalent heterobivalent inhibitor effectively inhibits anaphylaxis to peanut allergen in a humanized mouse model
- Clinton B. Mathias, Western New England Univ., Interleukin-10 enhances IL-33-mediated MC activation and modulates the development of food allergy
- Irina Miralda Molina, Seattle Children's Res. Inst., Ligation of Siglec- 9 inhibits FcεRI-dependent mediator release from human mast cells
- Tamara Salloum, Brigham and Women’s Hosp. and Harvard Med. Sch., Transcriptional profiling unveils the heterogeneity of constitutive and inducible mast cells in inflammation and homeostasis
- Adam James Moeser, Michigan State Univ., Androgen receptor deficiency eliminates sex differences in mast cells
- Chang-hyun Kim, Vigencell Inc., Immunomodulatory effects of human myeloid-derived suppressor cells expanded from cord blood on dermatophagoides farinae-induced atopic dermatitis in NC/Nga mice
- Brandon Lee, MIT, Novel association of lyme disease, age, and atopic dermatitis
Monday, May 9, 2022 10:15 AM – 12:15 PM Room A107–109
Innate Immune Response to Infection
Chairs
- Fayyez Sutterwala, Cedars-Sinai Med. Center
- Naeha Subramanian, Univ. of Washington
Speakers
- Christopher Michael Horn, Univ. of Nebraska Med. Ctr., Glycolysis is critical for granulocytic myeloid-derived suppressor cell (G-MDSC) activity during Staphylococcus aureus biofilm infection
- Maria J. Gonzalez Orozco, Univ. of Texas Med. Br. at Galveston, The E3-ligase TRIM7 acts as an antiviral factor by ubiquitinating the SARS-CoV-2 membrane protein to limit apoptosis and virus replication
- Jacob S. Yount, Ohio State Univ., Interferon-induced transmembrane protein 3 (IFITM3) limits lethality of SARS-CoV-2 in mice
- Smita Kulkarni, Texas Biomed. Res. Inst., Virus-induced long noncoding RNAs regulate SARS-CoV-2 pathogenesis
- Ajay Suresh Akhade, Inst. for Systems Bio., Seattle, A non-canonical role of caspase-1 in regulating bacterial physiology and antimicrobial resistance
- Jerod A. Skyberg, Univ. of Missouri-Columbia, Nucleotide receptors mediate protection against neonatal sepsis and meningitis caused by alpha-hemolysin expressing Escherichia coli K1
- Juselyn D. Tupik, Virginia-Maryland Col. of Vet. Med., The Goldilocks Conundrum: The protective and adverse roles of immunoregulation by NOD-like receptors (NLRs) during brucellosis
- Suman Gupta, Cedars Sinai Med. Ctr., Leptospira spp. are a potent activator of Type I IFN responses via the cGAS-STING pathway
Monday, May 9, 2022 10:15 AM – 12:15 PM Oregon Ballroom 203
Innate Lymphocytes and Innate-Like T Cells in Cancer
Chairs
- Robert Welner, Univ. of Alabama at Birmingham
- Murad R. Mamedov, Univ. of California, San Francisco
Speakers
- Valeriya Kuznetsova, Univ. of Alabama at Birmingham, Perturbed function of natural killer cells by inflammatory cytokines in acute (AML) and chronic (CML) myeloid leukemias
- Sylvia M. Cruz, Univ. of California Davis Med. Ctr., Characterization of the tumor immune microenvironment in soft tissue sarcoma patients undergoing surgery
- Monica Cho,Univ. of Wisconsin-Madison, CD155 axis modulation promotes natural killer cell-mediated graft-versus-tumor effects against osteosarcoma
- Xia Liu, St. Louis Univ., The fate and function of NK cells in the suppressive tumor microenvironment
- Narendiran Rajasekaran, Northern Arizona Univ., Assembly and localization of extracellular matrix protein fibronectin modulates Natural killer cell infiltration in tumor spheroids
- Clemence Riffard, INSERM, LTi-like type 3 innate lymphoid cells are associated with the transient induction of tertiary lymphoid structures in inflamed pulmonary tissue
- Murad R. Mamedov, Univ. of California, San Francisco, Genome-wide CRISPR screens reveal metabolic and transcriptional regulation of BTN3A and cancer susceptibility to VγVδ2 T cell targeting
Monday, May 9, 2022 10:15 AM – 12:15 PM Oregon Ballroom 201
Macrophages, Myeloid, and Dendritic Cells in Tumor Immunity and Immunotherapy
Chairs
- Evan Lind, Oregon Hlth. and Sci. Univ.
- Kenneth Murphy, Washington Univ. in St Louis Sch. of Medicine
Speakers
- Briaunna M.N. Minor, Univ. of Rochester Med. Ctr., Estradiol effects on polymorphonuclear cell production and actions contribute to estrogen-mediated lymphangioleiomyomatosis (LAM) progression
- Stacy K. Thomas, Perelman Sch. of Med., Univ. of Pennsylvania, Liver macrophage subsets differentially regulate metastasis in pancreatic cancer
- Irene Saha, Cincinnati Children's Hosp. and Med. Ctr., The B cell adapter for PI3K (BCAP) promotes M2 macrophage phenotype and safeguards tumors from immune surveillance
- David J. Friedman, Mayo Clin., Enhanced anti-tumor immunity in ST8Sia6 knockout mice
- Jiaying Zheng, Mayo Clin. Grad. Sch. of BioMed. Sci., Hv1 proton channels control myeloid landscape and promote glioma progression
- Patrick A. Flynn, Oregon Hlth. and Sci. Univ., Impact of constitutive FLT3 signaling on dendritic cell development and function in a genetically-engineered mouse model of Acute Myeloid Leukemia
- Renee Wu, Washington Univ. in St Louis Sch. of Med., Mechanisms of CD40-dependent cDC1 licensing beyond co-stimulation
Monday, May 9, 2022 12:30 PM – 2:30 PM Room B117–119
Innate Immune Sensing and Signaling
Chairs
- Yuan He, Wayne State Univ. Sch. of Med.
- Jian Zhang, Univ. of Iowa
Speakers
- Yilei Ma, Univ. of Iowa, E-Syt1 ubiquitination by Nedd4 limits the caspase-11-mediated non-canonical inflammasome and endotoxemia
- Yuan He, Wayne State Univ., Molecular basis for NEK7-mediated NLRP3 inflammasome activation
- Chi Gidley Weindel, Texas A&M Univ., Col. of Med., Gasdermin D promotes hyperinflammation by triggering necroptosis in the presence of mitochondrial stress
- Swathy Ollikara Vasudevan, UConn Hlth., A TLR4-independent critical role for CD14 in intracellular LPS sensing
- Matthew R. Rice, Feinstein Inst. for Med. Res., STK25 functions as an IRF5 kinase to promote TLR7/8-mediated inflammation
- Nayeon Son, Missouri State Univ., Identification of a novel protein interactions that elucidates the mechanism of hydatidiform molar pregnancies in women with NLRP2 and NLRP7 mutations
- Jamie L. Shirley, Univ. of Colorado Anschutz Med. Campus, PD-L1 back signaling manipulates IL-6 signaling to coordinate innate immune responses
Monday, May 9, 2022 12:30 PM – 2:30 PM Room B110–112
Neonatal Mucosal Immunity
Chairs
- Kathryn A. Knoop, Mayo Clin.
- Michael A. Silverman, Children's Hosp. of Philadelphia
Speakers
- Michael A. Silverman, Children's Hosp. of Philadelphia, Arresting microbiome development limits immune system maturation and resistance to infection
- Katherine Z. Sanidad, Weill Cornell Med., Gut microbiome regulates serotonin production in the neonatal intestine to promote immune tolerance in early life
- Mohammed Amir, Weill Cornell Med., Gut microbiota-reactive IgG regulates gut microbiota development and immunity against enteric pathogens in early life
- Kara G. Greenfield, Mayo Clin., Maternally derived epidermal growth factor mediates protection in neonates from opportunistic intestinal pathogens.
- Ellen Merrick Schill, Washington Univ. in St Louis Sch. of Med., Neonatal antibiotic exposure alters intestinal macrophage frequency and polarization
- Elizabeth Managlia, Ann & Robert H. Lurie Children's Hosp. of Chicago, CD206+MHCII- macrophages present in the neonatal but not adult intestine do not derive from LysM monocytes and are decreased in experimental Necrotizing Enterocolitis
- Julia A. Brown, Weill Cornell Med. Col., The preterm infant microbiome impairs lung immune responses to respiratory syncytial virus infection
Monday, May 9, 2022 3:45 PM – 5:45 PM Oregon Ballroom 201
CD8+ T Cells in Cancer
Chairs
- Andrea Schietinger, Memorial Sloan Kettering Cancer Ctr.
- David Masopust, Univ. of Minnesota
Speakers
- Michael William Rudloff, Vanderbilt Univ. Med. Ctr., Hallmark features of T cell dysfunction are established within hours after tumor antigen encounter
- Nataliya Prokhnevska, Emory Univ., CD8 T cell activation in cancer is comprised of two distinct phases
- Hazem E. Ghoneim, Ohio State Univ. Col. of Med., Rebalancing TGFβ1/BMP Signaling Epigenetically Reprograms Fully Exhausted Human CD8 T Cells into a Functional State
- Benjamin M. Murter, Univ. of Pittsburgh Sch. of Med., PIK3IP1/TrIP Immune Regulation on CD8+ T Cells Restricts Anti-Tumor Immunity
- Rachel Cantrell, Univ. of Cincinnati Col. of Med., The role of the Thrombin/PAR axis in modulating CD8+ T cell anti-tumor immunity
- Haitao Wen, Ohio State Univ., Sushi domain containing 2 suppresses CD8+ T cell antitumor immunity by targeting IL-2 receptor signaling
- Emily C. Lerner, Duke Univ. Sch. of Med., CD8 T cells licensed with immune checkpoint blockade kill murine tumors lacking MHC-I
- Pamela Rosato, Geisel Sch. of Med., Dartmouth Col., Functional virus-specific memory CD8+ T cells survey glioblastoma
Monday, May 9, 2022 3:45 PM – 5:45 PM Room C123–124
Molecular Regulation of Innate and Cytotoxic Lymphocyte Responses
Chair
- Jie Sun, Univ. of Virginia
Speakers
- Etienne Humblin, Icahn Sch. of Med. at Mount Sinai, CD28 signaling strength regulates the cell fate of TCF-1+ PD-1+ CD8 T cells
- Michael Battaglia, Univ. at Buffalo Sch. of Med. and BioMed. Sci., Ets1 regulates production of dendritic epidermal T cells (DETC) and cooperates with IL17Ra signaling to regulate immune responses to Staphylococcal skin infection
- Thomas Riffelmacher, La Jolla Inst. for Immunology, Metabolic fuel choices control MAIT cell functions at homeostasis and after infection
- Timofey Karginov, UConn Hlth., Optimal CD8+ T cell effector function requires costimulation-induced RNA-binding proteins that reprogram the transcript isoform landscape
- Eshana Mukhopadhyay, Cincinnati Children's Hosp. Med. Ctr., A role for a DEAD box RNA helicase in natural killer cells
- Mark Elliott Williams, Emory Univ. Sch. of Med., Lineage analysis defines subpopulations of human lung tissue-resident memory CD8+ T cells
- Reed M. Hawkins, Oregon Hlth. and Sci. Univ., Androgen receptor regulation of CD8 T cell immune responses
- Connie Krawczyk, Van Andel Inst., The sexually dimorphic histone demethylase promotes optimal T cell responses during infection
Monday, May 9, 2022 3:45 PM – 5:45 PM Room B117–119
Mucosal Immune Regulatory Mechanisms
Chairs
- Craig L. Maynard, Univ. of Alabama at Birmingham
- Meghan A. Koch, Fred Hutchinson Cancer Res. Ctr.
Speakers
- Susan Kovats, Oklahoma Med. Res. Fndn., Androgens protect ILC2s from interferon-mediated functional suppression during influenza virus infection
- Kaylyn Bauer, Univ. of Utah, Rab27A-dependent transfer of CD11c+ cell exosomes regulate gut immunity
- Marina Chulkina, Pennsylvania State Univ. Col. of Med., MyD88-mediated signaling in myo-/fibroblasts is required for control of macrophage maturation under mucosal tolerance in the gut
- Emma Erlich, Washington Univ. in St Louis Sch. of Med., B cells drive tertiary lymphoid organ formation in ileal inflammation
- Andrea Reboldi, Univ. of Massachusetts Med. Sch., IgA B cell receptor signaling protects from FasL counterselection during germinal center reaction in Peyer’s patches and shapes humoral mucosal response.
- Jason L. Kubinak, Univ. of South Carolina Sch. of Med., Defective humoral immunity disrupts bile acid homeostasis which promotes inflammatory disease of the small bowel
- Elisa Cruz Morales, Perelman Sch. of Med., Univ. of Pennsylvania, Analysis of the mechanisms that maintain intestinal regulatory T cells
- Warakorn Kulalert, NIH, Functional tuning of commensal-specific lymphocytes by nociceptive sensory neurons
