Postdoctoral Research Position–Long Lab
Benaroya Research Institute
Join our Team! This collaborative training position as a translational immunologist provides a unique opportunity to explore the potentially protective role of exhausted CD8 T cells in type 1 diabetes (T1D).
The Long Lab is a translational immunology lab focused on better understanding underlying mechanisms of autoimmune disease, patient variability, and response to therapy. Currently, we are primarily focused on three, inter-related projects in the setting of T1D:
- Causes and consequences of reduced response to IL-2
- Cellular definition and stability of CD8 T cell exhaustion associated with response to therapy, and
- identification of biomarkers of T1D severity.
Each of these projects use human samples, are collaborative in context working with the diabetes team, genomics and systems immunology, and use the resources of the BRI Human Immunophenotyping (HIP) Core, supervised by Dr. Alice Long.
The postdoctoral scientist conducts independent cellular and molecular research relevant to defining mechanisms underlying CD8 T cell exhaustion in the context of T1D (Long, et.al., Sci Imm, Wiedeman, et.al., JCI).
The applicant will:
- Design and perform experiments and analyses relevant to CD8 ‘exhausted’ cells found in T1D and molecular mechanisms that underlie differentiation, stability and function of these cells at different stages of disease
- Work with the Bioinformatics team at BRI to design and perform experiments
- Collaborate with leaders in the field of autoimmunity
- Publish papers, write grants and present findings at meetings
- Supervise support staff in the lab
- Be forward thinking by welcoming opportunities for additional training and engagement with the larger scientific community
- Foster a friendly, collaborative learning environment that prioritizes integrity and respect, innovation and agility, and constant inquiry
- Requires a Ph.D. in Immunology or a related field and experience in tissue culture, cellular and molecular techniques
- Demonstrated track record of technical proficiency, scientific creativity, collaboration with others, and independent thought
- Preferred: experience with cytometry and large data-sets
For more information, contact Alice Long at email@example.com.