Major Symposia
Saturday, May 7, 2022 8:00 AM – 11:30 AM Portland Ballroom 252–253
Major Symposium A
Development of the Immune System
Chairs
- Avinash Bhandoola, NCI, NIH
- Ellen V. Rothenberg, Caltech
Speakers
- Ellen V. Rothenberg, Caltech, Transcriptional and epigenetic regulation of single-cell decisions to enter the T cell developmental pathway
- Kenneth M. Murphy, Washington Univ. Sch. of Med. in St. Louis, Mechanisms of divergence during dendritic cell development
- Albert S. Bendelac, Univ. of Chicago, An ILC2-specific Gata3 enhancer
- Gretchen E. Diehl, Mem. Sloan Kettering Cancer Ctr., Development of microbiota specific T cells
- Gay M. Crooks, Univ. of California, Los Angeles, A dish of T: in vitro models of human T cell development
- Avinash Bhandoola, NCI, NIH, Transcriptional control of thymic epithelial cell development and its impact on T cell function
Saturday, May 7, 2022 8:00 AM – 11:30 AM Portland Ballroom 254–255
Major Symposium B
Macrophage Biology, Diversity, and Inflammation
Chairs
- Mireia Guerau-de-Arellano, The Ohio State Univ.
- Claudia V. Jakubzick, Geisel Sch. of Med. at Dartmouth
Speakers
- Claudia V. Jakubzick, Geisel Sch. of Med. at Dartmouth, Resident macrophage diversity in the lung
- Kristin L. Patrick, Texas A&M Univ., Defining the contribution of RNA-binding proteins to macrophage activation and innate immune gene expression
- Rafael Czepielewski, Washington Univ. Sch. of Med. in St. Louis, Lymphatics and tertiary lymphoid organs in IBD: Balancing immunity, inflammation and flow
- Jian Zhang, Univ. of Iowa, Regulation of innate immunity by E3 ubiquitin ligases
- Thirumala-Devi Kanneganti, St. Jude Children’s Res. Hosp., Targeting innate immunity and PANoptosis for the treatment of inflammatory and infectious diseases
- Edward B. Thorp, Northwestern Univ., Coordination of macrophage metabolism with tissue repair
Sunday, May 8, 2022 8:00 AM – 11:30 AM Portland Ballroom 252–253
Major Symposium C
Sex Differences in the Immune Response
Chairs
- Sabra L. Klein, Johns Hopkins Bloomberg Sch. of Pub. Hlth.
- Shannon E. Dunn, Univ. of Toronto, Canada
Speakers
- Sabra L. Klein, Johns Hopkins Bloomberg Sch. of Pub. Hlth. , SeXX differences in immunity to influenza and SARS-CoV-2
- Shannon E. Dunn, Univ. of Toronto, Canada, Sex differences in the effect of obesity on T helper 1 immunity
- Dawn C. Newcomb, Vanderbilt Univ. Med. Ctr., Sex hormones regulate allergic airway inflammation in asthma
- Jun R. Huh, Harvard Med. Sch., Pregnancy plays a major role in dictating viral-induced immune responses
- Bérénice A. Benayoun, Univ. of Southern California, Lifelong sex differences in neutrophil phenotypes
- Kanakadurga Singer, Univ. of Michigan, Sex differences in obesity-induced meta-inflammation
Sunday, May 8, 2022 8:00 AM – 11:30 AM Portland Ballroom 254–255
Major Symposium D
Maintaining Tissue Homeostasis during Initiation and Resolution of Inflammation
Chairs
- Daniel J. Campbell, Benaroya Res. Inst.
- Keke C. Fairfax, Univ. of Utah
Speakers
- Keke C. Fairfax, Univ. of Utah, Influence of bone marrow inflammation on tissue immunity
- Sarah L. Gaffen, Univ. of Pittsburgh, IL-17 signaling crosstalk during inflammation
- Gudrun F. Debes, Thomas Jefferson Univ., Skin regulatory B cells: homing and function
- Brian S. Kim, Icahn Sch. of Med. at Mount Sinai, Itch paradigms: neuroimmune regulation of somatosensation
- Daniel J. Campbell, Benaroya Res. Inst., Manipulating regulatory T cell activity in tissues to treat autoimmunity
Monday, May 9, 2022 8:00 AM – 11:30 AM Portland Ballroom 252–253
Major Symposium E
Tumor Microenvironment
Chairs
- Shannon J. Turley, Genentech
- Nikhil S. Joshi, Yale Univ. Sch. of Med.
Speakers
- Assaf Magen, Icahn Sch. of Med. at Mount Sinai, mregDC/T helper niches enable local reactivation of CD8+ T cells upon PD-1 blockade
- Nikhil S. Joshi, Yale Univ. Sch. of Med., Investigating T cell responses in engineered cancer models
- Greg M. Delgoffe, UPMC Hillman Cancer Ctr., Control of T cell differentiation by tumor microenvironment metabolism
- Shannon J. Turley, Genentech, Stromal-immune niches in cancer, inflammation, and immunotherapy
- Ming O. Li, Mem. Sloan Kettering Cancer Ctr., Immunological mechanisms of cancer defense
Monday, May 9, 2022 8:00 AM – 11:30 AM Portland Ballroom 254–255
Major Symposium F
B Cell Responses in Non-Lymphoid Tissues
Chairs
- Jennifer L. Gommerman, Univ. of Toronto, Canada
- Jeffrey L. Browning, Boston Univ. Sch. of Med.
Speakers
- Thomas Korn, Tech. Univ. of Munich, Germany, Building and controlling B cell niches in the CNS
- S. Rameeza Allie, Penn State Col. of Med., Resident memory B cells in the frontline of respiratory immunity
- Brad H. Nelson, BC Cancer–Victoria, Canada, Tumor-infiltrating B cells from diagnosis to end-stage disease in ovarian cancer
- Tullia C. Bruno, Univ. of Pittsburgh Sch. of Med., Exploring differential functions of B cells and tertiary lymphoid structures in human cancer
- F. Eun-Hyung Lee, Emory Univ., The bone marrow microniche and the maturation of human long-lived plasma cells
- Jennifer L. Gommerman, Univ. of Toronto, Canada, B cells and grey matter injury in an animal model of multiple sclerosis
Tuesday, May 10, 2022 8:00 AM – 11:30 AM Portland Ballroom 252–253
Major Symposium G
Immunology of COVID-19: Mechanisms of Pathology and Protection
Chairs
- Ali H. Ellebedy, Washington Univ. Sch. of Med. in St. Louis
- Deepta Bhattacharya, Univ. of Arizona
Speakers
- Ali H. Ellebedy, Washington Univ. Sch. of Med. in St. Louis, Germinal center B cell response to SARS-CoV-2
- Ivan Zanoni, Harvard Univ., Interferons: friends or foes in COVID-19?
- Michela Locci, Perelman Sch. of Med. at the Univ. of Pennsylvania, Immunological mechanisms of messenger RNA vaccines
- Paul G. Thomas, St. Jude Children’s Res. Hosp., Deconstructing the form and function of T cell responses to SARS-CoV-2
- Taia T. Wang, Stanford Univ., Structurally and functionally distinct antibody responses predict COVID-19 disease trajectory and mRNA vaccine response
- Deepta Bhattacharya, Univ. of Arizona, Antibody recall responses to heterologous SARS-CoV-2 infections
Tuesday, May 10, 2022 8:00 AM – 11:30 AM Portland Ballroom 254–255
Major Symposium H
New Insights into Autoimmunity and Immune Tolerance
Chairs
- Hongbo Chi, St. Jude Children’s Res. Hosp.
- Vijay K. Kuchroo, Brigham and Women’s Hosp.
Speakers
- Mandy J. McGeachy, Univ. of Pittsburgh, IL-17 from translation to function
- Vijay K. Kuchroo, Brigham and Women’s Hosp., Role of gut-resident stem-like Th17 cells in inducing tissue inflammation and autoimmunity
- Qizhi Tang, Univ. of California, San Francisco, Human Treg response to inflammation
- Hongbo Chi, St. Jude Children’s Res. Hosp., Nutrients: signal 4 for licensing T cell immunity and tolerance
- Vanja Lazarevic, NCI, NIH, Transcriptional regulation of CD4+ T cells that mediate neuroinflammation
- Richard A. Flavell, Yale Univ. Sch. of Med., Lessons from a humanized mouse model of COVID-19
