Mayo Clinic Arizona
A full-time postdoc position is available in the Borges da Silva laboratory at the Department of Immunology, Mayo Clinic: https://www.mayo.edu/research/faculty/borges-da-silva-henrique-ph-d/bio-20492923. We are in the Arizona campus, located in Scottsdale.
Our group aims to understand how extracellular nucleotide signaling regulates T cell responses to infection, autoimmunity, and cancer. Our group has found that one of these nucleotides, extracellular ATP, is fundamental for the generation and maintenance of memory CD8+ T cells (PMID: 29973721, PMID: 32640257, PMID: 35264459). We currently focus to further understand the molecular basis for such role, and to exploit this signaling axis to boost the ability of T cells to establish in response to immunization or solid tumors. We apply cutting-edge tools: CRISPR-Cas9 or retroviral vector-based gene manipulation, multi-dimension FACS, bulk and single-cell RNA-seq, using relevant mouse models of infection, autoimmunity, allergy, or cancer.
Specifically, the postdoc will focus on define how sensing of tumor-derived extracellular ATP regulates the immune response of Chimeric Antigen Receptor T cells (CAR-T cells) to control solid tumors, in a project recently funded by the Grohne Cancer Immunology and Immunotherapy Program at Mayo Clinic.
Candidates with a doctoral degree within 1 year (or about to get one) are especially encouraged to apply. Experience in lymphocyte biology, molecular/cellular immunology, in vivo mouse tumor models and/or transcriptomics is desired. Please send CV and contacts for up to two references to BorgesdaSilva.Henrique@mayo.edu.
Please also apply for this job at the following link: https://jobs.mayoclinic.org/job/scottsdale/research-fellow-immunology/33647/25428368784