Washington University School of Medicine
St. Louis, Missouri
Postdoctoral position in lymphocyte development, function and oncogenesis at Washington University School of Medicine
We are recruiting 1-2 postdoctoral fellows to study lymphocyte development, adaptive immune responses, and leukemogenesis/lymphomagenesis at the molecular levels. The goal is to understand cellular, genetic and epigenetic regulatory networks governing physiological and pathogenic hematopoiesis, adaptive immune responses to chronic viral infection and cancers and suppression of tumorigenesis in lymphocytes. Strong candidates are expected to have experience in molecular immunology and in vivo studies using mouse models or human large data analyses. Additional expertise in flow cytometry, epigenetic analyses, pathogen infection experiments and analysis of public human sequence databases is highly appreciated.
The position is in Department of Pathology and Immunology at Washington University School of Medicine, located in Saint Louis, USA. The lab is located in scientifically rich environment with close interaction with leading immunologists, including Ken Murphy, Marco Colonna, Wayne Yokoyama and Chyi-Song Hsieh. This is a great place to build a successful research career. Please refer to our research summary at https://pathology.wustl.edu/people/takeshi-egawa-md-phd/.
Please send CV, a brief statement of your past accomplishment and prospective goal (1-2 pages each), and email addresses of two or more references to: Takeshi Egawa, MD, PhD. at email@example.com.
- Xia Y, Sandor K, Pai JA, Daniel B, Raju S, Wu R, Hsiung S, Qi Y, Yangdon T, Okamoto M, Schreiber RD, Murphy KM, Satpathy AT*, Egawa T* (*co-corresponding authors). BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4 T cell responses to persistent antigen. bioRxiv 2021; doi: https://doi.org/10.1101/2021.08.06.455141
- Daniel B, Yost KE, Sandor K, Xia Y, Qi Y, Hiam-Galvez KJ, Meier SL, Belk JA, Giles JR, Wherry EJ, Chang HY, Egawa T*, Satpathy AT* (*co-corresponding authors). Divergent clonal differentiation trajectories of T cell exhaustion. bioRxiv 2021; doi: https://doi.org/10.1101/2021.12.16.472900
- Tonc E, Takeuchi Y, Chou C, Xia Y, Holmgren M, Fujii C, Raju S, Chang GS, Iwamoto M, Egawa T. Unexpected suppression of tumorigenesis by c-MYC via TFAP4-dependent restriction of stemness in B lymphocytes. Blood, 2021, 138 (24): 2526-2538. doi: 10.1182/blood.2021011711. PMID: 34283887. PMCID: PMC8678995.
- Raju S, Xia Y, Daniel B, Yost KE, Bradshaw E, Tonc E, Verbaro DJ, Kometani K, Yokoyama WM, Kurosaki T, Satpathy AT, Egawa T. Identification of a T-bethi quiescent exhausted CD8 T cell subpopulation that can differentiate into TIM3+ CX3CR1+ effectors and memory-like cells. J Immunol. 2021, 206(12): 2924-2936. doi: 10.4049/jimmunol.2001348. PMID: 34088768. PMCID: PMC8642473.
- Raju S, Verbaro DJ, Egawa T. PD-1 Signaling Promotes Control of Chronic Viral Infection by Restricting Type-I-Interferon-Mediated Tissue Damage. Cell Rep. 2019;29(9):2556-2564.e3. PMID: 31775026. PMCID: PMC6894421.
- Raju S, Kometani K, Kurosaki T, Shaw AS, Egawa T. The adaptor molecule CD2AP in CD4 T cells modulates differentiation of follicular helper T cells during chronic LCMV infection. PLoS Pathogen. 2018;14(5):e1007053.doi:10.1371/journal.ppat.1007053. eCollection 2018 May. PMID: 29734372. PMCID: PMC5957453.
- Chou C, Verbaro DJ, Tonc E, Holmgren M, Cella M, Colonna M, Bhattacharya D, Egawa T. The Transcription Factor AP4 Mediates Resolution of Chronic Viral Infection through Amplification of Germinal Center B Cell Responses. Immunity. 2016;20;45(3):570-582. PMID: 27566940. PMCID: PMC5037962.